The Effects of Low Dose Radiation: New Aspects of Radiobiological Research Prompted by the Chernobyl Nuclear Disaster

ISBN-13: 9789067644143 / Angielski / Twarda / 2004 / 420 str.

E. B. Burlakova; V. I. Naiditch

Opis

The papers collected in this book show the results of investigations performed by Russian scientists in the field of low dose irradiation action., which developed after the Chernobyl accident and studied its consequences. The main part of reviews and articles is devoted to the aspects of low dose effects on the human and animal genome and far post-irradiation consequences.

Spis treści

Introduction, The effect of low dose, low-level radiation on incidence rate and development of spontaneous leucosis in AKR mice, Quality of medical information in the Russian National Medical and Dosimetric Registry (RNMDR) for the Bryansk, Kaluga, Tula and Oryol Oblasts, Cytogenetic effects in human beings exposed to irradiation on the Earth and in space, The effect of epithelial thymus cells on post-irradiation apoptosis display of thymocytes in vitro, Radiation-induced genome instability: phenomenon, molecular mechanisms, pathogenic significance, Induced Mini- and Microsatellite Instability in the Genome of Animal Germline Cells, The Redox Homeostasis System in Radiation-Induced Genome Instability, Detection of genome instability in descendants of male mice exposed to chronic low-level y-irradiation using the test adaptive response, Signal function of reactive oxygen species in regulatory networks of the cell response to damaging exposures: participation in radiosensitivity realization and genome instability, Structural and functional changes induced by exposure to X-ray adaptive doses in human lymphocytes, both normal and defective, by DNA double strand break reparation, Response of a cell population to low-dose irradiation, The results of cytogenetic observation of children and teenagers inhabited in zones radiation-polluted after Chernobyl accident, Cytogenetic effects of low dose radiation in mammalian cells: the analysis of the phenomenon of hypersensitivity and induced radioresistance, A possible mechanism for the adaptive response induced in mammalian cells by low doses of radiation, The peculiar long term cellular alterations under low doses of ionizing radiation, Analysis of epidemiological data on radiocarcinogenic effects and approaches to determining the low-dose upper limit in terms of existence of biologically harmful effect threshold of ionizing radiation, Emotional stress and the problems of radiation medicine, Time- and dose-dependent post-irradiation changes of Fe3+-transferrinand Cu2+-ceruloplasmin pools in blood, influence on ribonucleotide reductase activity in animal tissues and the effects of radio protectors, The main principles of radiation biology, Modern problems of antiradiation chemical defense of organisms, Regularities of somatic mutagenesis in long dates after low dose ionizing radiation effect on human organism

O autorze

Valeria Naiditch, Elena Burlakova