The Drosophila Model in Cancer

ISBN-13: 9783030236281 / Angielski / Twarda / 2019 / 250 str.

Opis

In recent years, Drosophila , with its powerful genetic tools and in-depth knowledge of its biology, has contributed greatly in understanding the basics of cancer biology. This book is intended to collect writings from leading scientists who use the Drosophila model to address fundamental questions related to different areas of cancer research. The topics will range from identification of cancer related genes and pathways, to how tumor cells interact with its microenvironment; and from the intrinsic defense mechanisms metazoans have evolved, to why cancer is deadly. What we have learned from this small creature will continue to help in our fight against cancer.

Spis treści

Prelims

1.      Drosophila model in cancer: an introduction  

2.      Using Drosophila models and tools to understand the mechanisms of novel human cancer driver gene function

3.      The initial stage of tumorigenesis in Drosophila epithelial tissuesi  

4.      Drosophila models of cell polarity and cell competition in tumourigenesis

5.      Two sides of the same coin – compensatory proliferation in regeneration and cancer

6.      P53 and apoptosis in the Drosophila model  

7.      Autophagy and tumorigenesis in Drosophila

8.      Filling the gaps among obesity, the CDK8 module, and uterine tumors using Drosophila

9.      MicroRNAs in Drosophila cancer models

10.  Cancer Stem Cells and Stem Cell Tumors in Drosophila

11.  Drosophila as a model for tumor-induced organ wasting 

12.  Drosophila melanogaster as a model system for human glioblastomas

13.  What Drosophila Can Teach Us About Radiation Biology of Human Cancers

14.  A Drosophila based cancer drug discovery frameworkIn

Index.

O autorze

Wu-Min Deng is a Professor at the Department of Biological Sciences in Florida State University.

Blurb

This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics.  Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression.

 

Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use.  This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems.

 

This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.