The Diabetic Kidney

ISBN-13: 9781617376788 / Angielski / Miękka / 2010 / 564 str.

Pedro Cortes

Opis

A comprehensive and authoritative survey of recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. The authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Highlights include an entire section devoted to novel approaches to studying diabetic nephropathy with the most advanced molecular techniques, and complete descriptions of the most up-to-date views on the diagnosis and treatment of the disease. The Diabetic Kidney offers both researchers and practicing clinicians a clear understanding of the of the progress that has been made regarding the pathogenesis of diabetic nephropathy and of the therapeutic interventions needed to prevent its development or treat it.

Spis treści

Part I: Basic Pathophysiology and Biochemistry of Diabetic Nephropathy A. Pathophysiology Angiotensin II and Its Receptors in the Pathogenesis of Diabetic Nephropathy David J. Leehey, Ashok K. Singh, and Rekha Singh Altered Renal Microvascular Function in Early Diabetes Pamela K. Carmines, Joseph P. Bast, and Naohito Ishii B. Interstitial Disease Proteinuria and Interstitial Fibrogenesis in Diabetic Nephropathy Raimund Hirschberg C. Podocytes Podocytes and Diabetic Nephropathy George Jerums, Sianna Panagiotopoulos, and Richard MacIsaac D. Altered Metabolic Pathways Altered Glucose Transport and Its Metabolic Effects in Glomerular Cells Charles W. Heilig mRNA Translation in Diabetic Nephropathy Balakuntalam S. Kasinath, Myung Ja Lee, Denis Feliers, and Nahum Sonenberg The Hexosamine Biosynthesis Pathway: Contribution to the Pathogenesis of Diabetic Nephropathy I. George Fantus, Howard J. Goldberg, Catharine I. Whiteside, and Delilah Topic E. Nonenzymatic Glycosylation Glycation: Receptor for Advanced Glycation Endproducts and Diabetic Nephropathy Vivette D'Agati and Ann Marie Schmidt F. Oxidative Stress Oxidative and Glycooxidative Stress in Diabetic Nephropathy Frederick R. DeRubertis and Patricia A. Craven G. Growth Factors Connective Tissue Growth Factor in the Pathogenesis of Diabetic Nephropathy: A Target for Therapeutic Intervention Bruce L. Riser, Alessia Fornoni, and Sujatha Karoor Vascular Endothelial Growth Factor as a Determinant of Diabetic Nephropathy Geoffrey Boner and Mark E. Cooper Transforming Growth Factor-b Signal Transduction in the Pathogenesis of Diabetic Nephropathy: Identifying Molecular Targets for Therapeutic Intervention Sheldon Chen and Fuad N. Ziyadeh H. New Approaches to the Study of Diabetic Nephropathy Hepatocyte Growth Factor: Physiological and Therapeutic Ligand to Attenuate Diabetic Nephropathy Shinya Mizuno and Toshikazu Nakamura Proteomics in the Investigation of Diabetic Nephropathy Visith Thongboonkerd Gene Expression Profiling in the Investigation of Diabetic Nephropathy Katalin Susztak, Erwin Bottinger, and Kumar Sharma PPAR-g Ligands and Diabetic Nephropathy Keiji Isshiki, Daisuke Koya, and Masakazu Haneda a-Endosulfine in Diabetic Nephropathy Jerry Yee and Balazs Szamosfalvi The Prospect of a Novel Therapeutic, Bone Morphogenetic Protein-7, in Diabetic Nephropathy Keith A. Hruska, Laura DePetris, Tingting Li, Song Wang, Theresa Geurs, Frank Strebeck, Qing Chen, and Helen Liapis Part II: Clinical Aspects of Diabetic Nephropathy A. Genetics and Risks Genetic Determinants of Diabetic Nephropathy in Type 2 Diabetes Grzegorz Placha and Andrzej S. Krolewski Major Risk Indicators for Diabetic Kidney Disease Katherine R. Tuttle B. Histopathology and Special Populations The Structure of Human Diabetic Nephropathy Michael Mauer and Behzad Najafian Diabetic Kidney Disease in Transitional and Disadvantaged Populations E. Jennifer Weil and Robert G. Nelson C. Diagnosis and Treatment Screening and Treatment of Early Diabetic Renal Disease in Type 1 and Type 2 Diabetes Ellie Chuang and Mark E. Molitch Treatment in Advanced Renal Disease in Type 1 and Type 2 Diabetes Eberhard Ritz and Gunter Wolf Diabetic and Renal Disease: ACE Inhibitors and/or Angiotensin Receptor Blockers: Does It Matter? Carl Erik Mogensen and Niels Holmark Andersen Management of Diabetic End-Stage Renal Disease With Dialysis Ploumis S. Passadakis and Dimitrios G. Oreopoulos D. Rela

Blurb

Although diabetic kidney disease is the most prevalent cause of end-stage renal disease and the disease most often leading to chronic renal replacement therapy and kidney transplantation, there has been, in recent years, a steady increase in basic and clinical knowledge of the problem. In The Diabetic Kidney, a stellar group of international researchers and clinicians joins forces to independently survey recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. Drawing on many years of experience, the authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Not always in total agreement, their views reflect the present state of knowledge and its uncertainties, and offer a composite of different authoritative views on the causes of diabetic kidney disease. Highlights include an entire section devoted to novel approaches to studying diabetic nephropathy with the most advanced molecular techniques, and comprehensive descriptions of the most up-to-date views on the diagnosis and treatment of the disease.
State of the art and illuminating, The Diabetic Kidney offers both researchers and practicing clinicians a clear understanding of the progress that has been made regarding the pathogenesis of diabetic nephropathy and of the therapeutic interventions needed to prevent its development or treat it.