The Design and Analysis of Sequential Clinical Trials

ISBN-13: 9780471975502 / Angielski / Twarda / 1997 / 328 str.

John Whitehead;Whitehead

Opis

Sequential clinical trials are those where data from patients treated at the beginning of a trial can be analyzed while the trial is on-going and subsequent patients are recruited. This analysis provides stopping rules whereby the number of patients involved can be limited without affecting the results. This revised edition includes reference to PEST software (Planning and Education of Sequential Trials) and covers Bayesian Analysis of Sequential Trials.

Recenzje

"...This book is clear, it provides many details and is well written..." (Statistical Methods in Medical Research, No.11, 2002)

Spis treści

Clinical Trials.

Allocating Patients to Treatments.

Measurement of Treatment Difference.

The Design of a Sequential Trial Using the Boundaries Approach.

The Analysis of a Sequential Trial.

Alternative Approaches to the Design and Analysis of Sequential Clinical Trials.

Prognostic Factors.

The Comparison of More than Two Treatments.

Implementation of Sequential Methods: Some Examples.

References.

Appendix.

Index.