The Chemokine Receptors

ISBN-13: 9781617377686 / Angielski / Miękka / 2010 / 424 str.

Jeffrey K. Harrison; Nicholas W. Lukacs

Opis

G-protein coupled receptors (GPCRs) constitute a large superfamily of proteins that have been historically well represented as drug targets. As such, many of the volumes within The Receptors series have focused their attention on rec- tor subfamilies in the GPCR superfamily (e. g., adrenergic, serotonergic, do- minergic). While chemokine receptors are relatively young, in terms of the knowledge that has accumulated regarding their roles in physiology and pat- logy, it is clear that this GPCR subfamily is dwar? ng all others with respect to the total number of receptors and their functional diversity. The breadth of the chemokine ? eld was not fully appreciated in the early days of chemokine d- covery, when the characterization of these molecules was largely a curiosity of a small set of biologists primarily interested in in? ammation. Presently, the ? eld of chemokinology is quite diverse, and it is nearly impossible to stay informed on all aspects of chemokine biology. Nonetheless, this book seeks to distill information regarding the molecular and cell biology, physiology, and pathology of chemokines and their receptors into a single volume, providing an excellent resource for those entering the ? eld or the most experienced c- mokinologist seeking new insights. In the chapters, leading authorities consider structural and cellular aspects of chemokines and chemokine receptors, and more notably, discuss the roles of these molecules in a variety of disease states that transcend their classically de? ned role(s) in in? ammation.

Recenzje

From the reviews:

"This book aims to report the knowledge concerning chemokines and their receptors in the context of human physiology, pathology, and future therapeutic possibilities. ... this book gives an interesting analysis of the different fields of knowledge and research concerning chemokines and their receptors in recent years. In this way, this book remains interesting for less experienced and mature researchers ... ." (Liliane Gattegno, ChemMedChem, Issue 3, 2008)

"The Chemokine Receptors is an impressive and timely overview of the current knowledge in this field. The target readership includes researchers ... clinicians including infectiologists, rheumatologists, oncologists and others may surely find information in this book, shedding light on their field of medicine. As such, the book can be used both by people entering the field and by more experienced researchers seeking new insights. ... The volume contains numerous figures (including colour plates) as well as informative tables."(F. De Keyser, Acta Clinica Belgica, Vol. 63 (4), 2008)

Spis treści

The Chemokine Receptors, Editors: Jeffrey K. Harrison and Nicholas W. Lukacs Table of Contents Chapter 1. The Birth and Maturation of Chemokines and Their Receptors *Nicholas W. Lukacs, Ph.D. and *Jeffrey K. Harrison, Ph.D. University of Michigan and University of Florida 2. The Structural Biology of Chemokines *Elias Lolis, Ph.D. and James Murphy, Ph.D. Yale University 3. Chemokine Receptors: A Structural Overview *Gerard J. Graham, Ph.D. and Robert J. Nibbs, Ph.D. University of Glasgow 4. Chemokine Signalling in T Lymphocytes Migration: the Role of Phosphoinositide 3-kinase Laura Smith, Adam Webb, and *Stephen G. Ward, Ph.D. University of Bath 5. Chemokine Receptors and Neutrophil Trafficking *Teizo Yoshimura, M.D., Ph.D. National Cancer Institute at Frederick 6. Chemokine Receptors and Dendritic Cell Trafficking *Hiroyuki Yoneyama, M.D., Ph.D., Kenjiro Matsuno, M.D., Ph.D., and Kouji Matsushima, M.D., Ph.D. University of Tokyo 7. Chemokine Receptors and Lymphocyte Trafficking Michael N. Hedrick, Ph.D. and *Joshua M. Farber, M.D. National Institute of Allergy and Infectious Disease/National Institutes of Health 8. Chemokines in Trafficking of Hematopoietic Stem and Progenitor Cells and Hematopoiesis *Chang Kim, Ph.D. Purdue University 9. Chemokines in Transplantation Biology *Peter Jon Nelson, Ph.D., Stephan Segerer, M.D., and Detlef Schlondorff, M.D. University of Munich 10. The Chemokine System and Arthritis Marlon P. Quinones, M.D., Fabio Jimenez, Carlos A. Estrada, M.D., Herman Martiniez, M.D., and *Seema Ahuja, M.D. University of Texas-San Antonio 11. Chemokine Receptors in Atherosclerosis Maya R. Jerath, Mildred Kwan, Peng Liu, and *Dhavalkumar D. Patel, M.D., Ph.D. University of North Carolina 12. Chemokine Receptors in Allergic Lung Disease Dennis M. Lindell, Ph.D.and *Nicholas W. Lukacs, Ph.D. University of Michigan 13. Chemokine Receptors and HIV/AIDS *Tzanko S. Stanchev, M.D. and *Christopher C. Broder, Ph.D. Uniformed Services University of Health Sciences 14. Chemokines and Their Receptors in Fibrosis Glenda Trujillo, Ph.D. and *Cory M. Hogaboam, Ph.D. University of Michigan 15. Chemokines and Angiogenesis *Michael P. Keane, M.D., John A. Belperio, M.D., and Robert M. Strieter, M.D. University of California, Los Angeles and University of Virginia 16. Chemokine Receptors in Cancer: Pathobiology and Potential Therapeutic Targets Tonya C. Walser, Ph.D. and *Amy M. Fulton, Ph.D. University of Maryland 17. Chemokine Receptors in Neuroinflammation Astrid E. Cardona, Ph.D. and *Richard M. Ransohoff, M.D. Lerner Research Institute, Cleveland Clinic 18. Pharmaceutical Targeting of Chemokine Receptors *Sofia Rubiero, Ph.D. and Richard Horuk, Ph.D. Berlex Biosciences * indicates corresponding authors

Blurb

To date, there are over twenty different chemokine receptors, binding nearly fifty unique ligands that have been identified. In Chemokine Receptors, leading investigators attempt to distill the large body of literature ranging from basic molecular and cellular mechanism of chemokine receptors, to physiological and pathological roles of chemokines. Chemokines exhibit a tremendous functional diversity and participate in a wide variety of processes that include inflammation, innate and adaptive immunity, immune cell differentiation, angiogenesis, tumorigenesis, development, neurobiology and viral pathogenesis. Chemokine Receptors targets the pharmaceutical industry, provides an authoritative perspective on the future direction of this field, and insights into areas of active development of novel therapeutics.