The Chemical Biology of Thrombin

ISBN-13: 9781032203300 / Angielski / Miękka / 2024 / 268 str.

Roger L. Lundblad

Opis

Chemical Biology of Thrombin is a comprehensive review of thrombin as regulatory protease, perhaps one of the most important enzymes in hemostasis. It focuses on work from 1970's to the present time. Thrombin has some emerging therapeutic uses such the treatment of pseudoaneurysms and an important role in the extravascular space.

Spis treści

Preface. Acknowledgements. About the Author. The History of Thrombin. The Formation of Thrombin. Structural Biology of Thrombin. The Use of Protein Engineering (Mutagenesis) to Study Functional Regions in Thrombin Expression and Characterization of Recombinant Thrombins. Chemical Modification of Thrombin. The Interaction of Thrombin with Fibrinogen and Fibrin. Thrombin and Platelets. Inhibitors of Thrombin. Index.

O autorze

Roger L. Lundblad is an independent consultant based in Chapel Hill, North Carolina. He is also an adjunct professor of pathology at the University of North Carolina, Chapel Hill.