The Cerebellum, Epilepsy, and Behavior

ISBN-13: 9781461345107 / Angielski / Miękka / 2011 / 402 str.

Irving Cooper

Opis

In cats anesthetized lightly with pentobarbital or alpha-chloralose, electrical stimulation of the paramedian lobule of cerebellum resulted in a change of EEG pattern. Prior to stimulation the pattern consisted of h igh-ampl itude slow waves with superimposed low-ampl itude fast activity. In addition, the EEGs of animals anesthetized with chloralose showed "chloralose spikes." Immediately following brief cerebellar stimulation the slow wave activity and spikes disappeared, leaving only low-voltage fast activity. The effect was most pronounced in the contralateral leads from the rostral portions of the cerebrum. Study of the parameters most effective in evoking this effect revealed that stimulation frequency, train duration, and probably pulse duration affected the duration of suppression in a sigmoid fashion, with inflection points at approximately 90 Hz, 2.5 sec, and 1 msec, respectively. Above threshold values, stimulation cur rent showed an approximately linear relationship to duration of EEG sup pression. The after-discharge resulting from focal electrical stimulation of the cerebral cortex could be shortened by electrical stimulation of the para median lobule. The effect was essentially the same when cerebellar stim ulation preceded, occurred during, or followed the cerebral cortical stim ulation. The great variability of the after-discharge resulting from cerebral cortical stimulation as well as the variability of the effects of cerebellar stimulation made it impractical to study systematically the parameters op timal for shorten ing after-discharge. Such a study wi II require use of an awake, preferably partially restrained animal with electrodes chronically implanted."

Spis treści

Cerebellar Modifications of Abnormal Discharges in Cerebral Sensory and Motor Areas.- Changes in Spontaneous Neuronal Firing in Cerebellum Red Nucleus, and Raphe Nuclear Complex During Convulsive Activity.- Cerebellar Influences on the Hippocampus.- Experimental Cobalt Epilepsy and the Cerebellum.- Experimental Epilepsy: Cerebro-Cerebellar Interactions and Antiepileptic Drugs.- The Effect of Chronic Stimulation of Cerebellar Cortex on Epilepsy in Man.- Parameters of Motion and EMG Activities During Some Simple Motor Tasks in Normal Subjects and Cerebellar Patients.- Modulation of Spontaneous and Evoked Chloralose Myoclonus by Cerebellar Stimulation in the Cat (Relation to Ramsey Hunt Syndrome).- Cerebellar Cortical Stimulation Effects on EEG Activity and Seizure After-Discharge in Anesthetized Cats.- The Effect of Varying the Frequency of Cerebellar Stimulation Upon Epilepsy.- The Effects of Cerebellar Stimulation on the Averaged Sensory Evoked Responses in the Cat.- The Effect of Cerebellar Lesions on Emotional Behavior in the Rhesus Monkey.- Psychological Studies of Chronic Cerebellar Stimulation in Man.- Some Ethical Considerations of Cerebellar Stimulation as an Innovative Therapy in Humans.- Psychosurgery and Brain Stimulation: The Legislative Experience in Oregon in 1973.- Summary.