The Causation and Clinical Management of Pelvic Radiation Disease

ISBN-13: 9781447117063 / Angielski / Miękka / 2012 / 153 str.

Philip F. Schofield; Eric W. Lupton; S. Goldberg

Opis

Material for this book was gathered in the early 1980's in Manchester, where a higher incidence than usual of complications in the gastro-intestinal and urinary tract was observed. Part I describes the principles and methods of radiotherapy for pelvic tumours, pathological features and radiological analysis of bowel and urinary tract changes. Parts II and III are devoted to clinical assessment and management, where the need for a multi-diciplinary approach is emphasized.

Spis treści

1 General Principles.- 1 Radiotherapy Techniques.- Carcinoma Bladder.- Carcinoma Prostate.- Carcinoma Cervix.- Carcinoma Rectum.- References.- Suggested Further Reading.- 2 Pathology of Radiation Injury.- General Features of Radiation Injury.- Ectasia and Aneurysm Formation.- Occlusive Effect.- Arterial Medial Hypertrophy.- Pathology of Radiation Bowel Disease.- Small Intestine.- Large Intestine.- Pathogenesis of Late Radiation Bowel Disease.- Urinary Tract Injury.- Ureter.- Bladder.- References.- 3 Radiology of Radiation Injury.- Radiological Assessment: Methods of Investigation.- Small Bowel.- Large Bowel.- Urinary Tract.- Ultrasound and Computed Tomography.- Radiological Signs.- Small Bowel.- Large Bowel.- Urinary Tract.- References.- 2 Bowel Disorders.- 4 Clinical Features of Radiation Bowel Disease.- Immediate Reactions.- Late Radiation Disease.- Predisposing Factors.- Clinical Presentation.- Investigation of Late Radiation Bowel Disease.- Remote Radiation Disease.- Intestinal Obstruction.- Malabsorption.- Association with Rectal Carcinoma.- References.- 5 Experimental Findings in Radiation Bowel Disease.- Histological Changes in Blood Vessels.- Qualitative Vascular Changes.- Quantitative Vascular Changes.- Fibrin Thrombi and Injury to Vascular Endothelium.- Progression of Vascular Lesions and Latency of Bowel Injury.- Experimental Studies of the Microvasculature and Pathogenesis of Radiation Bowel Disease.- Intravascular Studies in Experimental Animals.- Intravascular Studies in Human Radiation Bowel Disease.- References.- 6 Treatment of Radiation Bowel Disease.- Prevention.- Treatment of Early Disease.- Treatment of Late Disease.- Medical Treatment.- Preparation and Timing for Surgery.- Operative Management.- Outcome on Follow Up.- References.- 3 Urinary Tract Disorders.- 7 Predisposing Factors, Clinical Features, Investigations: Radiation Urinary Tract Disease.- Immediate Reactions (Early Disease).- Late Disease.- Predisposing Factors.- Clinical Features.- Upper Urinary Tract Disorders.- Lower Urinary Tract Disorders.- Investigations.- References.- 8 Treatment of Radiation Urinary Tract Disease.- General Principles.- Conservative Treatment.- Pre-operative Preparation.- Operative Treatment.- Ureteric Disorders.- Bladder Disease.- Combined Urinary Tract and Bowel Problems.- Bladder Neck and Urethral Problems.- Post-operative Care.- Complications.- Prognosis.- References.- 9 Conclusions and the Future.