The Calcitonin Gene-Related Peptide Family: Form, Function and Future Perspectives

ISBN-13: 9789400791800 / Angielski / Miękka / 2014 / 236 str.

Deborah L Hay;Ian M Dickerson

Opis

In 1925, J. B. Collip (1925) reported that extracts of parathyroid gland contained an activity that raised calcium levels in the blood of parathyroidectomized animals, and suggested that this was due to a hormone produced in the parathyroid gland. The story of parathyroid hormone discovery was indicative of ever-increasing sophistication in sample preparation and protein isolation techniques. This paper resolved earlier controversies over the function of the parathyroid glands and c- trol of blood calcium. The year 1961 was a banner year for parathyroid research, in which the peptides parathyroid hormone and calcitonin were purified, and in which it was suggested that calcitonin could lower blood calcium (Copp and Cameron 1961). In 1982 it was discovered that in neurons the primary RNA transcript for calcitonin could be alternatively-spliced to give calcitonin gene-reated peptide (CGRP), and shortly thereafter amylin (previously named islet amyloid polyp- tide, IAPP) was identified and shown to have homology to CGRP. Since then a and b CGRP have been delineated and adrenomedullin and intermedin discovered, and this family of homologous peptides has emerged. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.

Spis treści

Molecular and functional evolution of the adrenomedullin family in vertebrates: what do fish studies tell us? Ligand binding and activation of the CGRP receptor Understanding amylin receptors The CGRP-receptor component protein (RCP): a regulator for CLR signaling The calcitonin peptide family: what can we learn from receptor knockout and transgenic mice Gene targeted mouse models of adrenomedullin signalling Genetic regulation of CGRP and its actions Vascular actions of CGRP and adrenomedullin: mechanisms and potential contribution to inflammation in the cutaneous microvasculature Insights into the function of intermedin/adrenomedullin 2 CGRP and adrenomedullin as pain-related peptides Amylinergic control of ingestive behaviour CGRP receptor antagonists for migraine: challenges and promises Calcitonin receptor (CTR) expression in embryonic, foetal and adult tissues: developmental and pathophysiological implications Future perspectives

Blurb

This book contains a comprehensive series of reviews on the calcitonin gene-related peptide (CGRP) family of peptides. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.

This volume includes chapters on:

• The adrenomedullin peptides and signalling
• Ligand binding and activation of the CGRP receptor
• Understanding amylin receptors
• The CGRP-receptor component protein
• The calcitonin peptide family
• Genetic regulation of CGRP
• Vascular actions of CGRP and adrenomedullin
• Intermedin/adrenomedullin 2 function
• CGRP and adrenomedullin as pain-related peptides
• Amylinergic control of ingestive behaviour
• Calcitonin receptors

This book discusses their receptors, physiological and pathophysiological functions and potential as clinical targets. It will appeal to researchers who study any of these peptides and those with an interest in migraine therapy due to the involvement of CGRP in this disorder. The book is unique because it brings together research on the whole peptide family for the first time in several years. It will be a useful reference volume for researchers in this area. This book will also appeal to researchers in the broader field of bioactive peptides.