The Brain Reward System

ISBN-13: 9781071611487 / Angielski / Miękka / 2021

Opis

This volume explores the latest techniques used to better understand the brain reward system with respect to neurotransmitters, brain structures, and connectivity. This book aims to show readers tested laboratory protocols to study neural circuitry and biological processes implicated in reward, and in neuropsychiatric disorders such as substance use disorders. The chapters are organized into four parts. Part One addresses classical techniques to study the brain reward system, including the curve shift paradigm in intracranial self-stimulation, stereotaxic surgery in rodents, and the use of brain lesions. Part Two focuses on neurochemical, behavioral, and chemogenetic techniques such as immunofluorescence for assessing adult hippocampal neurogenesis, and fast-scan voltammetry. Part Three highlights methods used to assess the rewarding potential of drugs including intracranial self-stimulation combined with drug injection, and the use of viral vectors. The Fourth Part introduces imaging and electrophysiology techniques such as positron emission tomography, in vivo electrophysiology, and fiber photometry. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and thorough, The Brain Reward System is a valuable resource for researchers interested in learning more about the current methods used to study the delineation of the brain reward system.

Spis treści

Series Preface…
Preface. . . 
Table of Contents…
Contributing Authors . . . 

Part I Classical Techniques to Study the Brain Reward System

1    Intracranial Self-Stimulation and the Curve-Shift Paradigm: A Putative Model to Study the Brain Reward System
Marc Fakhoury and Pierre-Paul Rompré

2    Stereotaxic Surgery in Rodents for Stimulation of the Brain Reward System
Brenda M. Geiger, Monika Irene, and Emmanuel N. Pothos

3     Characterizing the Neural Substrate of Reward with the Use of Specific Brain Lesions
Howard Casey Cromwell

Part II Neurochemical Behavioral and Chemogenetic Techniques

4     Assessment of Adult Hippocampal Neurogenesis: Implication for Neurodegenerative Diseases and Neurological Disorders
Farah Chamaa, Batoul Darwish, Nayef Saade, and Wassim Abou-Kheir

5     Fast-Scan Voltammetry for In Vivo Measurements of Neurochemical Dynamics
Carl J. Meunier and Leslie A. Sombers

6     Carbon Fiber Probes for Real-Time Monitoring of Dopamine
Helen N. Schwerdt, Ann M. Graybiel, and Michael J. Cima

7     Immune-to-Brain Signaling Effects on the Neural Substrate for Reward: Behavioral Models of Aversion, Anhedonia, and Despair
Anna Mathia Klawonn and Michael Fritz

8    Behavioral Tests for Assessing Pain and Nociception: Relationship with the Brain Reward System
Marc Fakhoury, Reem Habib Mohamad Ali Ahmad, Elie D. Al-Chaer, Nada B. Lawand

9     Chemogenetic (DREADD) Exploration of Circuits Mediating Reward-Motivated Attention
Hrishikesh Pattabhiraman and Ryan D. Ward

Part III Techniques for Assessing the Effect of Drug of Abuse

10     Intracranial Self-Stimulation: Using the Curve-Shift Paradigm to Assess the Abuse Potential of Drugs
Ritchy Hodebourg

11     Drug Self-Administration as a Model to Study the Reward System
Florence Allain and Anne-Noël Samaha

12     Viral Vectors for Studying Drug-Seeking Behavior
Arlene Martínez-Rivera, Caitlin E. Burgdorf, and Anjali M. Rajadhyaksha

13     Conditioned Place Preference Test for Assessing the Rewarding Effects of Drugs of Abuse
Todd Hillhouse and Adam Prus

Part IV Imaging and Electrophysiological Techniques

14     Positron Emission Tomography of the Reward System
Diego Romero-Miguel, Nicolás Lamanna-Rama, Marta Casquero-Veiga, Vanessa Gómez-Rangel, Manuel Desco, and María Luisa Soto-Montenegro

15     In Vivo Electrophysiology for Reward Anticipation and Processing
Laura A. Alba, Elizabeth Baker, and Katherine K.M. Stavropoulos

16     Fiber Photometry of Neural Activity in Specific Neural Circuit
Jinsong Yu, Yue Li, Mona N. Hussein, Zhongchao Wang, Jinxia Dai, and Gang Cao

17     Two-Photon Microscopy for Studying Reward Circuits of the Brain
Rafiq Huda, Leena Ali Ibrahim, and Bernard Bloem

Subject Index. . .