The Brain-Dead Organ Donor: Pathophysiology and Management » książka
The Brain-Dead Organ Donor: Pathophysiology and Management
ISBN-13: 9781493941865 / Angielski / Miękka / 2016 / 368 str.
The Brain-Dead Organ Donor: Pathophysiology and Management
ISBN-13: 9781493941865 / Angielski / Miękka / 2016 / 368 str.
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With cutting-edge guidelines on the effective management of potential organ donors and a comprehensive survey of brain death, as well as how to select suitable brain-dead donors, this multidisciplinary work benefits from the expertise of leading scientists.
Chapter 1
Introduction
Dimitri Novitzky and David K.C. Cooper
Chapter 2
Historical Aspects of the Diagnosis of Death
Félix Bacigalupo and Daniela Huerta Fernández
Chapter 3
The Determination of Brain Death
Curtis M. Keller, Boris Chulpayev, and Michael Hoffmann
Chapter 4
Legal Aspects of Declaration of Brain Death and Organ Donation
Ricky T. Munoz and Mark D. Fox
Chapter 5
Ethical Aspects of Declaration of Brain Death and Organ Donation
Mark D. Fox and Ricky T. Munoz
Chapter 6
Pathophysiology of Brain Death in Small Animal Models
Bernhard Floerchinger, Nicholas L. Tilney, and Stefan G. Tullius
Chapter 7
Pathophysiology of Brain Death and Effects of Hormonal Therapy in Large Animal Models
Dimitri Novitzky, Winston N. Wicomb, and David K.C. CooperChapter 8
The Efficacy of Thyroid Hormone Therapy in Brain-Dead Heart Donors: A Review of Thyroid Function in Health and Disease
Lawrence E. Shapiro and Tatiana Baron
Chapter 9
The Inflammatory Response to Brain Death
Anne Barklin, Christine Lodberg Hvas, and Else Toennesen
Chapter 10
The Influence of Brain Death and Intensive Care Management on Donor Organs: Assessment of Inflammatory Markers
Wayel Jassem and Susan V. Fuggle
Chapter 11
Brain-Death–Induced Inflammation: Possible Role of the Cholinergic Anti-Inflammatory Pathway
Simone Hoeger and Benito A. Yard Chapter 12 Innate Immunity and Injury During Brain Death: Opportunities for Intervention Marc A. Seelen, Henri G.D. Leuvenink, and Rutger J. Ploeg Selection of the Brain-Dead Potential Organ Donor Kadiyala V. Ravindra, Keri E. Lunsford, Paul C. Kuo Chapter 14 Infectious Disease Aspects of the Brain-Dead Potential Organ Donor Nicole M. Theodoropoulos and Michael G. Ison Chapter 15 Malignancy in the Brain-Dead Organ Donor Michael A. Nalesnik, Ron Shapiro, and Michael G. Ison Chapter 16 Early Clinical Experience of Hormonal Therapy in the Brain-Dead Potential Organ Donor Dimitri Novitzky, Burcin Ekser, and David K.C. Cooper Chapter 17 Assessment, Monitoring, and Management of the Brain-Dead Potential Organ Donor Demetrios Demetriades and Lydia Lam Chapter 18 Assessment, Monitoring and Management of Brain-Dead Potential Organ Donors in Europe Gabriel J. Echeverri and Bruno G. Gridelli Chapter 19 Current Management of Brain Dead Donors in Australia Peter S. Macdonald, Anders Aneman, Deepak Bhonagiri, Daryl Jones, Gerry O’Callaghan, Helen Opdam, William Silvester, and Geoffrey J. Dobb (on behalf of the Australian Deceased Donor Management Research Group[1]) Chapter 20 Management of the Brain-Dead Organ Donor—Perspectives of the Transplant Coordinator Nicole T. Farina and David K.C. Cooper Chapter 21 Surgical Aspects of Thoracic and Abdominal Organ Procurement from Brain-Dead Donors Michael J. Anstadt, Paul C. Kuo, and Kadiyala V. Ravindra Chapter 22 Impact of Brain Death on Storage of the Heart Winston N. Wicomb and David K.C. Cooper Chapter 23 Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies Coney Bae, Anthony Watkins, Scot D. Henry, and James V. Guarrera Chapter 24 Functional Repair of Brain Death-Induced Injury Henri G.D. Leuvenink, Marc A.J. Seelen, and Rutger J. Ploeg Chapter 25 Functional Repair of Brain-Death-Injured Donor Lungs Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee Chapter 26 Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor Dimitri Novitzky and David K.C. Cooper Chapter 27 Current and Potential Future Trends in the Management of the Brain-Dead Organ Donor Octavio E. Pajaro and James K. Kirklin Chapter 28 Maximizing Utilization of the Potential Deceased Donor—The Challenge Continues Eliezer Katz
Chapter 12
Innate Immunity and Injury During Brain Death: Opportunities for Intervention
Marc A. Seelen, Henri G.D. Leuvenink, and Rutger J. Ploeg
Chapter 13Selection of the Brain-Dead Potential Organ Donor
Kadiyala V. Ravindra, Keri E. Lunsford, Paul C. Kuo
Chapter 14
Infectious Disease Aspects of the Brain-Dead Potential Organ Donor
Nicole M. Theodoropoulos and Michael G. Ison
Chapter 15
Malignancy in the Brain-Dead Organ Donor
Michael A. Nalesnik, Ron Shapiro, and Michael G. Ison
Chapter 16
Early Clinical Experience of Hormonal Therapy in the Brain-Dead Potential Organ Donor
Dimitri Novitzky, Burcin Ekser, and David K.C. Cooper
Chapter 17
Assessment, Monitoring, and Management of the Brain-Dead Potential Organ Donor
Demetrios Demetriades and Lydia Lam
Chapter 18
Assessment, Monitoring and Management of Brain-Dead Potential Organ Donors in Europe
Gabriel J. Echeverri and Bruno G. Gridelli
Chapter 19
Current Management of Brain Dead Donors in Australia
Peter S. Macdonald, Anders Aneman, Deepak Bhonagiri, Daryl Jones, Gerry O’Callaghan, Helen Opdam, William Silvester, and Geoffrey J. Dobb (on behalf of the Australian Deceased Donor Management Research Group[1])
Chapter 20
Management of the Brain-Dead Organ Donor—Perspectives of the Transplant Coordinator
Nicole T. Farina and David K.C. Cooper
Chapter 21
Surgical Aspects of Thoracic and Abdominal Organ Procurement from Brain-Dead Donors
Michael J. Anstadt, Paul C. Kuo, and Kadiyala V. Ravindra Chapter 22 Impact of Brain Death on Storage of the Heart Winston N. Wicomb and David K.C. Cooper Chapter 23 Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies Coney Bae, Anthony Watkins, Scot D. Henry, and James V. Guarrera Chapter 24 Functional Repair of Brain Death-Induced Injury Henri G.D. Leuvenink, Marc A.J. Seelen, and Rutger J. Ploeg Chapter 25 Functional Repair of Brain-Death-Injured Donor Lungs Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee Chapter 26 Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor Dimitri Novitzky and David K.C. Cooper Chapter 27 Current and Potential Future Trends in the Management of the Brain-Dead Organ Donor Octavio E. Pajaro and James K. Kirklin Chapter 28 Maximizing Utilization of the Potential Deceased Donor—The Challenge Continues Eliezer Katz
Chapter 22
Impact of Brain Death on Storage of the Heart
Winston N. Wicomb and David K.C. Cooper
Chapter 23
Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies
Coney Bae, Anthony Watkins, Scot D. Henry, and James V. Guarrera
Chapter 24
Functional Repair of Brain Death-Induced Injury
Henri G.D. Leuvenink, Marc A.J. Seelen, and Rutger J. Ploeg
Chapter 25
Functional Repair of Brain-Death-Injured Donor Lungs
Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee
Chapter 26
Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor
Dimitri Novitzky and David K.C. Cooper
Chapter 27
Current and Potential Future Trends in the Management of the Brain-Dead Organ Donor
Octavio E. Pajaro and James K. Kirklin
Chapter 28
Maximizing Utilization of the Potential Deceased Donor—The Challenge Continues
Eliezer Katz
Chapter 12
Innate Immunity and Injury During Brain Death: Opportunities for Intervention
Marc A. Seelen, Henri G.D. Leuvenink, and Rutger J. Ploeg
Chapter 13Selection of the Brain-Dead Potential Organ Donor
Kadiyala V. Ravindra, Keri E. Lunsford, Paul C. Kuo
Chapter 14
Infectious Disease Aspects of the Brain-Dead Potential Organ Donor
Nicole M. Theodoropoulos and Michael G. Ison
Chapter 15
Malignancy in the Brain-Dead Organ Donor
Michael A. Nalesnik, Ron Shapiro, and Michael G. Ison
Chapter 16
Early Clinical Experience of Hormonal Therapy in the Brain-Dead Potential Organ Donor
Dimitri Novitzky, Burcin Ekser, and David K.C. Cooper
Chapter 17
Assessment, Monitoring, and Management of the Brain-Dead Potential Organ Donor
Demetrios Demetriades and Lydia Lam
Chapter 18
Assessment, Monitoring and Management of Brain-Dead Potential Organ Donors in Europe
Gabriel J. Echeverri and Bruno G. Gridelli
Chapter 19
Current Management of Brain Dead Donors in Australia
Peter S. Macdonald, Anders Aneman, Deepak Bhonagiri, Daryl Jones, Gerry O’Callaghan, Helen Opdam, William Silvester, and Geoffrey J. Dobb (on behalf of the Australian Deceased Donor Management Research Group[1])
Chapter 20
Management of the Brain-Dead Organ Donor—Perspectives of the Transplant Coordinator
Nicole T. Farina and David K.C. Cooper
Chapter 21
Surgical Aspects of Thoracic and Abdominal Organ Procurement from Brain-Dead Donors
Michael J. Anstadt, Paul C. Kuo, and Kadiyala V. Ravindra Chapter 22 Impact of Brain Death on Storage of the Heart Winston N. Wicomb and David K.C. Cooper Chapter 23 Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies Coney Bae, Anthony Watkins, Scot D. Henry, and James V. Guarrera Chapter 24 Functional Repair of Brain Death-Induced Injury Henri G.D. Leuvenink, Marc A.J. Seelen, and Rutger J. Ploeg Chapter 25 Functional Repair of Brain-Death-Injured Donor Lungs Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee Chapter 26 Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor Dimitri Novitzky and David K.C. Cooper Chapter 27 Current and Potential Future Trends in the Management of the Brain-Dead Organ Donor Octavio E. Pajaro and James K. Kirklin Chapter 28 Maximizing Utilization of the Potential Deceased Donor—The Challenge Continues Eliezer Katz
Chapter 22
Impact of Brain Death on Storage of the Heart
Winston N. Wicomb and David K.C. Cooper
Chapter 23
Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies
Coney Bae, Anthony Watkins, Scot D. Henry, and James V. Guarrera
Chapter 24
Functional Repair of Brain Death-Induced Injury
Henri G.D. Leuvenink, Marc A.J. Seelen, and Rutger J. Ploeg
Chapter 25
Functional Repair of Brain-Death-Injured Donor Lungs
Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee
Chapter 26
Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor
Dimitri Novitzky and David K.C. Cooper
Chapter 27
Current and Potential Future Trends in the Management of the Brain-Dead Organ Donor
Octavio E. Pajaro and James K. Kirklin
Chapter 28
Maximizing Utilization of the Potential Deceased Donor—The Challenge Continues
Eliezer Katz
Chapter 22
Impact of Brain Death on Storage of the Heart
Winston N. Wicomb and David K.C. Cooper
Chapter 23
Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies
Coney Bae, Anthony Watkins, Scot D. Henry, and James V. Guarrera
Chapter 24
Functional Repair of Brain Death-Induced Injury
Henri G.D. Leuvenink, Marc A.J. Seelen, and Rutger J. Ploeg
Chapter 25
Functional Repair of Brain-Death-Injured Donor Lungs
Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee
Chapter 26
Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor
Dimitri Novitzky and David K.C. Cooper
Chapter 27
Current and Potential Future Trends in the Management of the Brain-Dead Organ Donor
Octavio E. Pajaro and James K. Kirklin
Chapter 28
Maximizing Utilization of the Potential Deceased Donor—The Challenge Continues
Eliezer Katz
The Efficacy of Thyroid Hormone Therapy in Brain-Dead Heart Donors: A Review of Thyroid Function in Health and Disease
Lawrence E. Shapiro and Tatiana Baron
Chapter 9
The Inflammatory Response to Brain Death
Anne Barklin, Christine Lodberg Hvas, and Else Toennesen
Chapter 10
The Influence of Brain Death and Intensive Care Management on Donor Organs: Assessment of Inflammatory Markers
Wayel Jassem and Susan V. Fuggle
Chapter 11
Brain-Death–Induced Inflammation: Possible Role of the Cholinergic Anti-Inflammatory Pathway
Simone Hoeger and Benito A. Yard Chapter 12 Innate Immunity and Injury During Brain Death: Opportunities for Intervention Marc A. Seelen, Henri G.D. Leuvenink, and Rutger J. Ploeg Selection of the Brain-Dead Potential Organ Donor Kadiyala V. Ravindra, Keri E. Lunsford, Paul C. Kuo Chapter 14 Infectious Disease Aspects of the Brain-Dead Potential Organ Donor Nicole M. Theodoropoulos and Michael G. Ison Chapter 15 Malignancy in the Brain-Dead Organ Donor Michael A. Nalesnik, Ron Shapiro, and Michael G. Ison Chapter 16 Early Clinical Experience of Hormonal Therapy in the Brain-Dead Potential Organ Donor Dimitri Novitzky, Burcin Ekser, and David K.C. Cooper Chapter 17 Assessment, Monitoring, and Management of the Brain-Dead Potential Organ Donor Demetrios Demetriades and Lydia Lam Chapter 18 Assessment, Monitoring and Management of Brain-Dead Potential Organ Donors in Europe Gabriel J. Echeverri and Bruno G. Gridelli Chapter 19 Current Management of Brain Dead Donors in Australia Peter S. Macdonald, Anders Aneman, Deepak Bhonagiri, Daryl Jones, Gerry O’Callaghan, Helen Opdam, William Silvester, and Geoffrey J. Dobb (on behalf of the Australian Deceased Donor Management Research Group[1]) Chapter 20 Management of the Brain-Dead Organ Donor—Perspectives of the Transplant Coordinator Nicole T. Farina and David K.C. Cooper Chapter 21 Surgical Aspects of Thoracic and Abdominal Organ Procurement from Brain-Dead Donors Michael J. Anstadt, Paul C. Kuo, and Kadiyala V. Ravindra Chapter 22 Impact of Brain Death on Storage of the Heart Winston N. Wicomb and David K.C. Cooper Chapter 23 Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies Coney Bae, Anthony Watkins, Scot D. Henry, and James V. Guarrera Chapter 24 Functional Repair of Brain Death-Induced Injury Henri G.D. Leuvenink, Marc A.J. Seelen, and Rutger J. Ploeg Chapter 25 Functional Repair of Brain-Death-Injured Donor Lungs Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee Chapter 26 Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor Dimitri Novitzky and David K.C. Cooper Chapter 27 Current and Potential Future Trends in the Management of the Brain-Dead Organ Donor Octavio E. Pajaro and James K. Kirklin Chapter 28 Maximizing Utilization of the Potential Deceased Donor—The Challenge Continues Eliezer Katz
Chapter 12
Innate Immunity and Injury During Brain Death: Opportunities for Intervention
Marc A. Seelen, Henri G.D. Leuvenink, and Rutger J. Ploeg
Chapter 13Selection of the Brain-Dead Potential Organ Donor
Kadiyala V. Ravindra, Keri E. Lunsford, Paul C. Kuo
Chapter 14
Infectious Disease Aspects of the Brain-Dead Potential Organ Donor
Nicole M. Theodoropoulos and Michael G. Ison
Chapter 15
Malignancy in the Brain-Dead Organ Donor
Michael A. Nalesnik, Ron Shapiro, and Michael G. Ison
Chapter 16
Early Clinical Experience of Hormonal Therapy in the Brain-Dead Potential Organ Donor
Dimitri Novitzky, Burcin Ekser, and David K.C. Cooper
Chapter 17
Assessment, Monitoring, and Management of the Brain-Dead Potential Organ Donor
Demetrios Demetriades and Lydia Lam
Chapter 18
Assessment, Monitoring and Management of Brain-Dead Potential Organ Donors in Europe
Gabriel J. Echeverri and Bruno G. Gridelli
Chapter 19
Current Management of Brain Dead Donors in Australia
Peter S. Macdonald, Anders Aneman, Deepak Bhonagiri, Daryl Jones, Gerry O’Callaghan, Helen Opdam, William Silvester, and Geoffrey J. Dobb (on behalf of the Australian Deceased Donor Management Research Group[1])
Chapter 20
Management of the Brain-Dead Organ Donor—Perspectives of the Transplant Coordinator
Nicole T. Farina and David K.C. Cooper
Chapter 21
Surgical Aspects of Thoracic and Abdominal Organ Procurement from Brain-Dead Donors
Michael J. Anstadt, Paul C. Kuo, and Kadiyala V. Ravindra Chapter 22 Impact of Brain Death on Storage of the Heart Winston N. Wicomb and David K.C. Cooper Chapter 23 Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies Coney Bae, Anthony Watkins, Scot D. Henry, and James V. Guarrera Chapter 24 Functional Repair of Brain Death-Induced Injury Henri G.D. Leuvenink, Marc A.J. Seelen, and Rutger J. Ploeg Chapter 25 Functional Repair of Brain-Death-Injured Donor Lungs Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee Chapter 26 Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor Dimitri Novitzky and David K.C. Cooper Chapter 27 Current and Potential Future Trends in the Management of the Brain-Dead Organ Donor Octavio E. Pajaro and James K. Kirklin Chapter 28 Maximizing Utilization of the Potential Deceased Donor—The Challenge Continues Eliezer Katz
Chapter 22
Impact of Brain Death on Storage of the Heart
Winston N. Wicomb and David K.C. Cooper
Chapter 23
Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies
Coney Bae, Anthony Watkins, Scot D. Henry, and James V. Guarrera
Chapter 24
Functional Repair of Brain Death-Induced Injury
Henri G.D. Leuvenink, Marc A.J. Seelen, and Rutger J. Ploeg
Chapter 25
Functional Repair of Brain-Death-Injured Donor Lungs
Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee
Chapter 26
Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor
Dimitri Novitzky and David K.C. Cooper
Chapter 27
Current and Potential Future Trends in the Management of the Brain-Dead Organ Donor
Octavio E. Pajaro and James K. Kirklin
Chapter 28
Maximizing Utilization of the Potential Deceased Donor—The Challenge Continues
Eliezer Katz
Chapter 12
Innate Immunity and Injury During Brain Death: Opportunities for Intervention
Marc A. Seelen, Henri G.D. Leuvenink, and Rutger J. Ploeg
Chapter 13Selection of the Brain-Dead Potential Organ Donor
Kadiyala V. Ravindra, Keri E. Lunsford, Paul C. Kuo
Chapter 14
Infectious Disease Aspects of the Brain-Dead Potential Organ Donor
Nicole M. Theodoropoulos and Michael G. Ison
Chapter 15
Malignancy in the Brain-Dead Organ Donor
Michael A. Nalesnik, Ron Shapiro, and Michael G. Ison
Chapter 16
Early Clinical Experience of Hormonal Therapy in the Brain-Dead Potential Organ Donor
Dimitri Novitzky, Burcin Ekser, and David K.C. Cooper
Chapter 17
Assessment, Monitoring, and Management of the Brain-Dead Potential Organ Donor
Demetrios Demetriades and Lydia Lam
Chapter 18
Assessment, Monitoring and Management of Brain-Dead Potential Organ Donors in Europe
Gabriel J. Echeverri and Bruno G. Gridelli
Chapter 19
Current Management of Brain Dead Donors in Australia
Peter S. Macdonald, Anders Aneman, Deepak Bhonagiri, Daryl Jones, Gerry O’Callaghan, Helen Opdam, William Silvester, and Geoffrey J. Dobb (on behalf of the Australian Deceased Donor Management Research Group[1])
Chapter 20
Management of the Brain-Dead Organ Donor—Perspectives of the Transplant Coordinator
Nicole T. Farina and David K.C. Cooper
Chapter 21
Surgical Aspects of Thoracic and Abdominal Organ Procurement from Brain-Dead Donors
Michael J. Anstadt, Paul C. Kuo, and Kadiyala V. Ravindra Chapter 22 Impact of Brain Death on Storage of the Heart Winston N. Wicomb and David K.C. Cooper Chapter 23 Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies Coney Bae, Anthony Watkins, Scot D. Henry, and James V. Guarrera Chapter 24 Functional Repair of Brain Death-Induced Injury Henri G.D. Leuvenink, Marc A.J. Seelen, and Rutger J. Ploeg Chapter 25 Functional Repair of Brain-Death-Injured Donor Lungs Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee Chapter 26 Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor Dimitri Novitzky and David K.C. Cooper Chapter 27 Current and Potential Future Trends in the Management of the Brain-Dead Organ Donor Octavio E. Pajaro and James K. Kirklin Chapter 28 Maximizing Utilization of the Potential Deceased Donor—The Challenge Continues Eliezer Katz
Chapter 22
Impact of Brain Death on Storage of the Heart
Winston N. Wicomb and David K.C. Cooper
Chapter 23
Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies
Coney Bae, Anthony Watkins, Scot D. Henry, and James V. Guarrera
Chapter 24
Functional Repair of Brain Death-Induced Injury
Henri G.D. Leuvenink, Marc A.J. Seelen, and Rutger J. Ploeg
Chapter 25
Functional Repair of Brain-Death-Injured Donor Lungs
Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee
Chapter 26
Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor
Dimitri Novitzky and David K.C. Cooper
Chapter 27
Current and Potential Future Trends in the Management of the Brain-Dead Organ Donor
Octavio E. Pajaro and James K. Kirklin
Chapter 28
Maximizing Utilization of the Potential Deceased Donor—The Challenge Continues
Eliezer Katz
Chapter 22
Impact of Brain Death on Storage of the Heart
Winston N. Wicomb and David K.C. Cooper
Chapter 23
Impact of Brain Death on Abdominal Organs and Allograft Preservation Strategies
Coney Bae, Anthony Watkins, Scot D. Henry, and James V. Guarrera
Chapter 24
Functional Repair of Brain Death-Induced Injury
Henri G.D. Leuvenink, Marc A.J. Seelen, and Rutger J. Ploeg
Chapter 25
Functional Repair of Brain-Death-Injured Donor Lungs
Jonathan C. Yeung, Marcelo Cypel, and Shaf Keshavjee
Chapter 26
Thyroid Hormone Therapy to the Recipient of a Heart from a Brain-Dead Donor
Dimitri Novitzky and David K.C. Cooper
Chapter 27
Current and Potential Future Trends in the Management of the Brain-Dead Organ Donor
Octavio E. Pajaro and James K. Kirklin
Chapter 28
Maximizing Utilization of the Potential Deceased Donor—The Challenge Continues
Eliezer Katz
Addressing all aspects of brain death and thoroughly detailing how a potential organ donor should be maintained to ensure maximum use of the organs and cells, The Brain-Dead Organ Donor: Pathophysiology and Management is a landmark addition to the literature. This first-of-its-kind, multidisciplinary volume will be of interest to a large section of the medical community. The first section of the book reviews the historical, medical, legal, and ethical aspects of brain death. That is followed by two chapters on the pathophysiology of brain death as investigated in small and large animal models. This includes a review of the many hormonal changes, including the neuroendocrine- adrenergic ‘storm’, that takes place during and following the induction of brain death, and how they impact metabolism. The next section of the book reviews various effects of brain death, namely its impact on thyroid function, the inflammatory response that develops, and those relating to innate immunity. The chapters relating to assessment and management of potential organ donors will be of interest to a very large group of transplant surgeons and physicians as well as critical care and neurocritical care physicians and nurses. Neurologists, endocrinologists, neurosurgeons, and pathologists will also be interested, especially in the more basic science sections on various aspects of brain-death and hormonal therapy. Organ procurement organizations and transplant coordinators worldwide will also be interested in this title. Other chapters will be of interest to medical historians, medico-legal experts, and ethicists.
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