The Blood-Brain Barrier and Its Microenvironment: Basic Physiology to Neurological Disease

ISBN-13: 9780849398926 / Angielski / Twarda / 2005 / 544 str.

Elga de Vries; Alexandre Prat

Opis

This reference analyzes the cellular and molecular biology and mechanisms of the blood-brain barrier (BBB) and presents the most recent studies on the role of the BBB in the development and initiation of a wide range of physiological and pathological conditions affecting the central nervous system.

Spis treści

Development of the Blood-Brain Barrier. Blood-Brain Barrier Genomics and Proteomics. Tight Junctions of the Blood-Brain Barrier. Trophic Factors and Cerebrovascular Regulation. Neuronal Influence at the BBB and Local Control of Microcirculation. The Transport Systems of the Blood-Brain Barrier. Drug Delivery Through the BBB: Non Viral Vectors. Immune Functions of Brain Endothelial Cells. T Cell Migration Across the Blood-Brain Barrier in CNS Inflammatory Diseases. Endothelial ICAM-1 Mediated Signalling and Its Role During Lymphocyte Migration into the CNS Parenchyma. Monocyte Migration across the BBB. Cerebral Perivascular Macrophages and the Blood-Brain Barrier. Chemokines at the Blood-Brain Barrier. Matrix Metalloproteinase and Proteolytic Opening of the Blood-Brain Carrier in Neuroinflammation. Endothelial cells, Extracellular Matrix and Astocytes: Interplay for Managing the Blood-Brain Barrier. Molecular Modulation of the Blood-Brain Barrier During Stroke. Apolipoprotein E, the Blood-Brain Barrier and Alzheimer's Disease. Techniques for Measuring the Blood-Brain Barrier Integrity. Influence of Brain Trauma on Blood-Brain Barrier Properties. Non-HIV Viral Interaction with the BBB

O autorze

Elga de Vries, Alexandre Prat