The Biology of Krüppel-Like Factors

ISBN-13: 9784431547006 / Angielski / Miękka / 2014 / 258 str.

Ryozo Nagai (Department of Cardiovascula;Scott L Friedman;Masato Kasuga

Opis

Kruppel-like factors (KLFs) are attracting great attention across a wide spectrum of biological sciences and medicine because of their remarkable biological potency and the diversity of roles they play in the physiological and pathological changes of cells and tissues. This book is a comprehensive compendium of the latest research on the molecular mechanisms of KLFs, describing their roles in transcriptional regulation, cellular differentiation and development, the pathogenesis of the liver and cardiovascular systems and cancer, and generation of ES cells and iPS cells. As the only concise treatise written to date by leading experts in the field, it serves as an authoritative review of this family of molecules and is an essential reference for all who are interested in KLFs. The book also explores the potential of KLFs as targets for novel therapeutics and diagnostics, and will be invaluable in those fields.

Spis treści

Overview.- Krüppel-like Factors: Ingenious Three Fingers Directing Biology and Pathobiology.- Molecular Control of Krüppel-like Factor Function.- Molecular Structures of Krüppel-like Factors.- Krüppel-like Factor Proteins and Chromatin Dynamics.- Co-regulator Interactions in Krüppel-like Factor Transcriptional Programs.- Krüppel-like Factors in Development and Differentiation.- Developmental Expression of Krüppel-like Factors.- Expanded Role for EKLF/KLF1 Within the Hematopoietic Lineage.- Roles of Krüppel-like Factors in Lymphocytes.- Krüppel-like Factors in Gastrointestinal Tract Development and Differentiation.- Gene Interactions Between Krüppel-like Factors in Development.- Krüppel-like Factors in Stem Cell Biology.- Krüppel-like Factors in Organ Function and Disease.- Krüppel-like Factors and the Liver.- Role of Krüppel-like Factor 15 in Adipocytes.- Krüppel-like Factors in the Heart.- Krüppel-like Factors in the Vascular Endothelium.- Krüppel-like Factors KLF2, KLF4, and KLF5: Central Regulators of Smooth Muscle Function.- Krüppel-like Factors in Cancers.- Diagnostic and Therapeutic Applications of Krüppel-like Factors.- Krüppel-like Factors KLF6 and KLF6-SV1 in the Diagnosis and Treatment of Cancer.- Drug Development and Krüppel-like Factors.