The Biology of Gastric Cancers

ISBN-13: 9780387691817 / Angielski / Twarda / 2008 / 332 str.

Timothy Wang; James Fox; Andy Giraud

Opis

As someone who has spent nearly half his life wondering about the relationship between Helicobacter and gastric cancer, I find this textbook on the subject exciting and timely. In fact, I am not aware of any other volume that has been able to distil so much new knowledge into such a comprehensive account of a poorly understood field. Taking my own view, as a scientist placed in the middle of the spectrum between basic science and clinical medicine, I can see that the editors, Jim Fox, Andy Giraud, and Timothy Wang, provide a broad mix of expertise, which ensures that the subject is treated with the right balance. From clinicopathologic observations in humans, to epidemiology, through animal models, to molecular and cell biology, this team has hit the mark for most readers. Fox is a well-known leader in animal models with broad expertise. He pioneered the field with observations on Helicobacter species in animals, from the time when only one spiral gastric bac- rium was known, "Campylobacter pyloridis. " Fox partners with Wang, whose team recently announced a dramatic advance in the field of carcinogenesis--the obser- tion that bone marrow-derived stem cells participate in the changes that become cancer. To this nice mix has been added Andy Giraud from my own country, who brings to the table some remarkable genetic models of gastric cancer based on alterations in the gp130/stat3-signaling pathway.

Spis treści

Overview and Pathology of Gastric Cancer.- Epidemiology of Gastric Cancer and Helicobacter pylori.- Diet and Gastric Cancer.- MALT Lymphoma: Clinicopathologic Features and Molecular Pathogenesis.- Gastrointestinal Stromal Tumors of Gastric Origin.- Human Gastric Neuroendocrine Neoplasia: Current Pathologic Status.- Gastric Neuroendocrine Neoplasia.- Epstein-Barr Virus and Gastric Cancer.- Role of Host Genetic Susceptibility in the Pathogenesis of Gastric Cancer.- Cancer Genetics of Human Gastric Adenocarcinoma.- Genomic and Proteomic Advances in Gastric Cancer.- Animal Models of Gastric Carcinoma.- Insights into the Development of Preneoplastic Metaplasia: Spasmolytic Polypeptide-Expressing Metaplasia and Oxyntic Atrophy.- Deregulation of E-Cadherin in Precancerous Lesions and Gastric Cancer.- Role of CagA in Helicobacter pylori Infection and Pathology.- The Role of Helicobacter pylori Virulence Factors in Rodent and Primate Models of Disease.- Host Immunity in the Development of Gastric Preneoplasia.- Atrophy and Altered Mesenchymal—Epithelial Signaling Preceding Gastric Cancer.- Genetic Models of Gastric Cancer in the Mouse.- Prostaglandin and Transforming Growth Factor ? Signaling in Gastric Cancer.- REG Proteins and Other Growth Factors in Gastric Cancer.- Role of Bone Marrow—Derived Cells in Gastric Adenocarcinoma.- Stromal Cells and Tumor Microenvironment.- Future Prospects for Helicobacter pylori Vaccination.

Blurb

There have been many impressive advances in our understanding of the pathogenesis of gastric adenocarcinoma, gastric MALT lymphoma, gastrointestinal stromal tumors of the stomach, and gastric carcinoid tumors over the years. "The Biology of Gastric Cancers," edited by Dr. Timothy Wang, Dr. James Fox and Dr. Andy Giraud, pays homage to the cutting edge concepts of cancer stem cells, tumor microenvironment, chronic inflammation, and genetic susceptibility to cancer and represents the very first volume devoted to the subject of the basic biology of gastric cancer. With an emphasis on animal models, but also considerable attention to human studies, host genetics and the role of bacterial factors and other environmental factors influencing the pathogenesis of gastric cancer, the topics presented in this book should be of interest to clinicians and investigators interested in gastrointestinal cancer, as well as basic investigators in related areas of cancer research. This body of work will hopefully stimulate clinical and translational studies that will advance early diagnosis and treatment of gastric tumors.