The Bacterial Spore: From Molecules to Systems

ISBN-13: 9781555816759 / Angielski / Twarda / 2017 / 397 str.

Ams

Opis

The study of bacterial spores spans biosecurity to ecology The first articles describing the sporulation process were published by Robert Koch and Ferdinand Cohn in the late 19th century. Although most of the work accomplished in the past 50 years has focused on the model organism Bacillus subtilis, more recent work significantly expanded the scope of sporulation research to integrate medically relevant spore pathogens, such as B. anthracis and Clostridium difficile, as well as investigations of the ecology of spore-forming species. This new direction is supported by an explosion of novel techniques that can also be applied to nonmodel organisms, such as next-generation sequencing, metagenomics, and transcriptomics. The Bacterial Spore provides a comprehensive series of reviews of the major topics in spore biology that represent intensive, cutting-edge spore research. Editors Adam Driks and Patrick Eichenberger assembled chapters written by a team of diverse and multidisciplinary experts in biodefense and microbial forensics to produce an overview of topics of spore research, such as spore molecular biology, bioremediation, systems biology, issues in biodefense, and the challenge of food safety that is accessible to any reader, regardless of expertise. The Bacterial Spore also encompasses the diversity of spore research, which will appeal to those seeking to broaden their knowledge. The Bacterial Spore is a reference for a wide range of readers, including geneticists, cell biologists, physiologists, structural and evolutionary biologists, applied scientists, advanced undergraduate and graduate students, and nonresearchers, such as national security professionals.

Recenzje

"The Bacterial Spore: From Molecules to Systems is an ambitious effort at consolidating this body of research in a way that highlights the biological diversity of bacterial spore formers, their industrial and medical applications, and fundamental mechanistic insights gained from their study in a way that is accessible to both the novice and expert microbiologist."

Spis treści

ContributorsPrefaceI. General Overview of The Bacillaceae and Clostridia1. Genome Diversity of Spore-Forming Firmicutes2. Evolution in the Bacillaceae3. Ecology of Bacillaceae4. Sporulation in Bacteria: Beyond the Standard ModelII. The Bacillaceae: Bacillus Subtilis5. Chance and Necessity in Bacillus subtilis Development6. Bacillus subtilis Systems Biology: Applications of -Omics Techniques to the Study of Endospore Formation7. Protein Targeting during Bacillus subtilis Sporulation8. Spore Peptidoglycan9. The Spore Coat10. Spore Resistance Properties11. Spore GerminationIII. The Bacillaceae: Bacillus Anthracis12. The Phylogeny of Bacillus cereus sensu lato13. The Bacillus anthracis Exosporium: What's the Big "Hairy" Deal?14. Animal Models for the Pathogenesis, Treatment, and Prevention of Infection by Bacillus anthracisIV. The Clostridia15. Physiology and Sporulation in Clostridium16. Clostridium perfringens Sporulation and Sporulation-Associated Toxin ProductionV. Practical Technologies17. Spore Surface Display18. The Role of Bacterial Spores in Metal Cycling and Their Potential Application in Metal Contaminant BioremediationIndex