The Baboon in Biomedical Research

ISBN-13: 9780387759906 / Angielski / Twarda / 2008 / 391 str.

John L. Vandeberg; Sarah Williams-Blangero; Suzette D. Tardif

Opis

Nonhuman primates have played critical roles in biomedical research, and they are among the few animals whose use in research continues to increase. The scienti?c value of nonhuman primates derives from their close phylogenetic proximity to man and their consequent anatomic, physiologic, and genetic similarities to man. Only nonhuman primates can provide adequate models for many complex physiological and disease processes of humans. The baboon is a relative newcomer to the repertoire of nonhuman primates used in biomedical research. However, in less than 50 years since its ?rst use in the U. S., it has become one of the most popular laboratory primate species. It is larger than the other widely used monkey species, making it advantageous for many types of experiments and technological developments. It is extraordinarily hardy and highly fecund in captivity. It closely resembles humans in a variety of physiological and disease processes, such as cholesterol metabolism, early stages of atherosclerosis, and alcoholic liver disease. Its chromosomes closely resemble those of humans, and many genes of the two species lie in the same chromosomal order. Among all primates, baboons are the most widely used models for the genetics of susceptibility to complex diseases and they are the ?rst nonhuman primate for which a framework genetic linkage map was established. In addition, the baboon genome is currently being sequenced, and as a result the utility of this species for biomedical research will be dramatically increased.

Spis treści

Preface John L. VandeBerg, Sarah Williams-Blangero, Suzette D. Tardif Introduction John L. VandeBerg The Development and Status of the Baboon Genetic Linkage Map Jeffrey A. Rogers, Michael C. Mahaney, Laura A. Cox The Study of Captive Baboon Behavior Linda Brent Spontaneous Pathology of Baboons Gene B. Hubbard Growth and Development of Baboons Steven R. Leigh Reproductive Biology of Baboons Erika K. Honoré, Suzette D. Tardif Microbiology of Captive Baboons Richard Eberle, Uriel Blas-Machado, Roman F. Wolf, Gray L. White Baboon Model for Endometriosis Thomas M. D’Hooghe, Cleophas M. Kyama, Jason M. Mwenda The Baboon in Embryology and Teratology Research Andrew G. Hendrickx, Pamela E. Peterson Baboon Models for Neonatal Lung Disease Bradley A. Yoder, Donald C. McCurnin, Jacqueline J. Coalson The Baboon Model for Dental Development Leslea J. Hlusko, Michael C. Mahaney Baboon Model for Dyslipidemia and Atherosclerosis David L. Rainwater, John L. VandeBerg Baboon Model for the Study of Nutritional Influences on Pregnancy Peter W. Nathanielsz, Mark J. Nijland, Christian H. Nevill, Susan L. Jenkins, Gene B. Hubbard, Thomas J. McDonald, Natalia E. Schlabritz-Loutsevitch Baboon Model for Infant Nutrition glen E. Mott, Douglas S. Lewis Baboon Model for Ingestive Behaviors John R. Blair-West, Derek A. Denton, Robert E. Shade, Richard S. Weisinger Baboon Model for Alcoholic Liver Disease: 1973-2003 Charles S. Lieber, Maria A. Leo, Leonore M. DeCarli Baboons in Drug Abuse Research Robert D. Hienz, Elise M. Weerts Neuroimaging of Baboons Kevin J. Black, Tamara Hershey, Stephen M. Moerlein, Joel S. Perlmutter The Baboon Model of Epilepsy: Current Applications inBiomedical Research C. Ákos Szabó, M. Michelle Leland, Koyle D. Knape, Jeff T. Williams The Baboon in Xenotransplant Research Leonard L. Bailey

Blurb

Building on the foundation of two earlier volumes, The Baboon in Biomedical Research returns in an updated edition that presents the variety of uses and the importance of the baboon in biomedical research today. With contributions from leading researchers who use the baboon model, the new edition, edited by John L. VandeBerg, Suzette D. Tardif, and Sarah Williams-Blangero, provides a cogent introduction to this nonhuman primate model and serves as a valuable guide for researchers as well as laboratory animal veterinarians.

The volume begins with a chapter on the baboon gene map, the first genetic linkage map developed for any nonhuman primate species. Subsequent chapters present the results of decades of research on basic biological characteristics of baboons: microbiology, reproductive biology, growth and development, behavior, and spontaneous pathology. The remaining chapters summarize the scientific contributions of baboons as models of human diseases or physiological or developmental characteristics, including neonatal lung disease, dental development, dyslipidemia and atherosclerosis, pregnancy, ingestive behaviors, infant nutrition, alcoholic liver disease, drug abuse, neuroimaging, epilepsy, and xenotransplantation. The baboon already has a 50-year history of significant contributions as a model for human states of health and disease. This volume highlights the exciting research that is currently being conducted with this animal model and suggests future directions for the baboon in biomedical research.