The Autoimmune Diseases

ISBN-13: 9780128121023 / Angielski / Twarda / 2019 / 1532 str.

Noel R. Rose; Ian R. MacKay

Spis treści

Section 1: Immunologic Basis of Autoimmunity 1. Prelude: Historical introduction to autoimmunity and autoimmune disease 2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity 3. General Features of Autoimmune Diseases 4. Antigen Presentation, Dendritic Cells, and Autoimmunity 5. T cells and their subsets 6. Role of Th1 Th2 Th17 Cells in Autoimmunity 7. Tolerance and Autoimmunity: T Cells 8. Regulatory T Cells 9. B Cells and Autoimmunity 10. Immunological memory T cells 11. Immunological memory B cells 12. Apoptotic Cells as a Source of Autoantigens 13. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes 14. Functional Effects of Autoantibodies 15. Cytokine Chemokines 16. Signaling Pathways in T and B Lymphocytes 17. HLA Genetics and Autoimmunity 18. Non HLA Genetics 19. AIRE related Autoimmunity 20. Immune Deficiencies and Autoimmunity 21. Infections and Autoimmunity 22. Noninfectious Environmental Agents and Autoimmunity 23. Sex, Pregnancy and Autoimmunity 24. Animal Models of Autoimmune Disease

Section 2: Multisystem Diseases 25. Systemic Lupus Erythematosus 26. Systemic Sclerosis, Scleroderma 27. Antiphospholipid Syndrome 28. Sjogren Syndrome 29. Rheumatoid Arthritis 30. Spondyloarthritis and Chronic Idiopathic Arthropathies 31. Myositis 32. Thyroid Disease 33. Type 1 Diabetes 34. Adrenalitis 35. Polyendocrine Syndromes 36. Gastritis and Pernicious Anemia 37. Hypophysitis 38. Hemolytic Anemia 39. Thrombocytopenic Purpura 40. Neutropenia 41. Aplastic Anemia 42. Clotting Disorders 43. Multiple Sclerosis 44. Peripheral Neuropathy 45. Myasthenia Gravis 46. Ocular Disease 47. Inner Ear Disease 48. Celiac Disease 49. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn's Disease 50. Chronic Hepatitis 51. Primary Billiary Cirrhosis 52. Primary Sclerosing Cholangitis 53. Pancreatitis 54. Bullous Skin Diseases: Pemphigus and Pemphigoid 55. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria 56. Kidney Disease: Goodpasture's Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis 57. Orchitis and Male Infertility 58. Oophoritis 59. Rheumatic Heart Disease 60. Myocarditis and Dilated Cardiomyopathy 61. Necrotizing Arteritis and Small Vessel Vasculitis 62. Large and Medium Vessel Vasculitides 63. Autoimmune Disorders of the Lung 64. Paraneoplastic Diseases 65. Antibody-Associated Neurological Diseases 66. Autoinflammatory and other Related Diseases

Section 3: Diagnosis, Prevention, and Therapy 67. Autoantibody Assays, Testing, and Standardization 68. Prediction of Autoimmune Disease 69. Emerging Therapies for Autoimmune Diseases 70. Postlude