Thallium-201 and Technetium-99m-Pyrophospate Myocardial Imaging in the Coronary Care Unit

ISBN-13: 9789400989061 / Angielski / Miękka / 2011 / 266 str.

F. J. T. Wackers

Opis

Noninvasive visualization of myocardial infarction using radionuclides dates back over eighteen years. Edward A. Carr and William H. Beierwaltes were first to report (1962) successful external imaging of myocardial infarcts in dogs and in man using an Anger scintillation camera. They demonstrated that after intravenous administration of 86Rb or l3ICS an infarct was visualized as a "cold spot," while 203Hg-labeled-chlormeridin resulted in a "hot-spot" image of the infarct. Since then, there have been major developmental improvements in avail able radionuclides, scintillation cameras and computer processing capabilities. In particular, the development of mobile gamma cameras opened the possi bility to obtain high quality images even at the bedside of critically ill patients. Since the development in 1974 of a new radiopharmaceutical, 20lTI and the application of 99mTc-pyrophosphate for myocardial imaging, these imaging agents are widely used for the detection of acute myocardial infarction. However, for practical application, frequently there appears to be uncertainty or even confusion concerning the relative merits of each method."

Spis treści

1. Instrumentation for radionuclide cardiology.- Accumulation of Radiopharmaceuticals.- 2. Mechanisms of thallium-201 myocardial accumulation.- 3. Mechanisms of technetium-99m-pyrophosphate accumulation in damaged myocardium.- Normal Scintigraphic Images.- 4. Thallium-201 myocardial imaging.- 5. Technetium-99m-pyrophosphate myocardial imaging.- Acute Myocardial Infarction.- 6. Thallium-201 myocardial imaging in acute myocardial infarction.- 7. Technetium-99m-pyrophosphate myocardial imaging in acute myocardial infarction.- 8. Comparative value and limitations of thallium-201 and technetium-99m-pyrophosphate myocardial imaging in acute myocardial infarction.- 9. Dual imaging in acute myocardial infarction.- Unstable Angina Pectoris.- 10. Thallium-201 myocardial imaging in unstable angina and variant angina.- 11. Technetium-99m-pyrophosphate myocardial imaging in unstable angina.- Myocardial Imaging in Patients with Atypical Chest Pain.- 12. Thallium-201 myocardial imaging as a selection method for the coronary care unit.- 13. Technetium-99m-pyrophosphate myocardial imaging in patients with atypical chest pain.- Concluding Remarks.- 14. Myocardial imaging with thallium-201 and technetium-99m-pyro-phosphate in the coronary care unit: conclusion.- 15. Self-assessment questions.