Textbook of Personalized Medicine

ISBN-13: 9783030620790 / Angielski / Twarda / 2020 / 744 str.

Kewal K. Jain

Spis treści

Preface to the 3rd edition

 

1 Basic Aspects

Definition of personalized medicine

History of medical concepts relevant to personalized medicine

Molecular biological basis of personalized medicine

Basics technologies for developing personalized medicine

‘Omics’ and personalized medicine

Conventional medicine versus personalized medicine

Personalized medicine and evidence-based medicine

Role of genetics in future approaches to healthcare

Role of systems biology in personalized medicine

Synthetic biology and development of personalized medicines

Personalized digital medicine

A personalized approach to environmental factors in disease

Reclassification of diseases

Translational science and personalized medicine

Personalization of multimodal therapies

 

2 Molecular Diagnostics in Personalized Medicine

Introduction

Molecular diagnostic technologies

               Sequencing

Biochips and microarrays

SNP genotyping

Detection of copy number variations

Study of rare variants in pinpointing disease-causing genes

Optical Mapping

Proteomics in molecular diagnosis

Role of nanobiotechnology in molecular diagnostics

Role of biosensors in personalized medicine

Gene expression profiling

Molecular imaging and personalized medicine

Combination of diagnostics and therapeutics

Point-of-care diagnosis

Genetic testing for disease predisposition

Combination of diagnostics with therapeutics

Future of molecular diagnostics in personalized medicine

 

3 Role of Biomarkers in Personalized Medicine

 

4 Pharmacogenetics

Basics of pharmacogenetics

Role of molecular diagnostics in pharmacogenetics

Role of pharmacogenetics in pharmaceutical industry

Clinical implications of pharmacogenetics

Limitations of pharmacogenetics

Pharmacoepigenomics vs pharmacogenetics in drug safety

Future role of pharmacogenetics in personalized medicine

 

5 Pharmacogenomics

Introduction

Basics of pharmacogenomics

Pharmacogenomics and drug discovery

Pharmacogenomics and clinical trials

Pharmacogenomic aspects of major therapeutic areas

Current status and future prospects of pharmacogenomics

 

6 Role of Pharmacoproteomics

Basics of proteomics

Proteomic approaches to the study of pathophysiology of diseases

Proteomic technologies for drug discovery and development

Applications of pharmacoproteomics in personalized medicine

 

7 Role of Metabolomics in Personalized Medicine

Metabolomics and metabonomics

Metabolomics bridges the gap between genotype and phenotype

Metabolomics, biomarkers and personalized medicine

Metabolomic technologies

Pharmacometabonomics

Metabonomic technologies for toxicology studies

Metabonomics/metabolomics and personalized nutrition

Metabolomics for personalized medicine

 

8 Role of Nanobiotechnology in Development of Personalized Medicine

 

9 Personalized Biological Therapies

Introduction

Recombinant human proteins

Therapeutic monoclonal antibodies

Cell therapy

Gene therapy

Personalized vaccines

Antisense therapy

 

10 Personalized Non-pharmacological Therapies

Introduction

Acupuncture

Personalized hyperbaric oxygen therapy

Personalized nutrition

Personalized physical exercise

Personalized surgery

 

11 Personalized Therapy of Cancer

 

12 Personalized Therapy of Neurological Disorders

 

13 Personalized Therapy of Psychiatric Disorders

 

14 Personalized Therapy of Cardiovascular Disorders

 

15 Personalized Therapy of Pulmonary Disorders      

 

16 Personalized Therapy Infectious Diseases

 

17 Personalized Approaches in Immunology

 

18 Personalized Management of Genetic Disorders

 

19 Personalized Management of Miscellaneous Disorders

Personalized management of DNA repair disorders

Personalized preventive medicine

Personalized management of ophthalmic disorders         

Personalized management of skin disorders

Personalized urology

Personalized therapy of rheumatoid arthritis

Personalized management of obesity

Personalized management of diabetes

Management of genetic disorders

Personalized management of gastrointestinal disorders

Personalized approaches to improve organ transplantation

Personalized approaches to addiction

Personalized geriatrics

Personalized pediatrics

Personalized nephrology

Personalized gynecology

 

20 Development of Personalized Medicine

Introduction

Non-genomic factors in the development of personalized medicine

Players in the development of personalized medicine

Role of genetic banking systems and databases

Role of bioinformatics in development of personalized medicine

Integration of technologies for personalized medicine

Global scope of personalized medicine

Advantages of personalized medicine

Limitations of personalized medicine

Future of personalized medicine

 

21 Ethical Aspects of Personalized Medicine

 

22 Legal Aspects of Personalized Medicine

 

23 Regulatory Aspects of Personalized Medicine

FDA and personalized medicine

FDA and molecular diagnostics in relation to personalized medicine

Regulatory aspects of pharmacogenetics

Regulation of direct-to-consumer genetic testing

FDA and pharmacogenomics

FDA and predictive medicine

 

24 Economics of Personalized Medicine

 

25 Future of Personalized Medicine

O autorze

Prof. K. K. Jain MD, FRACS, FFPM

Jain PharmaBiotech

Blaesiring 7

CH-4057 Basel, Switzerland

Blurb

This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considersgenetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients.

 This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various playersin it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed.

 Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of information for students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries.