Textbook of Ion Channels Volume III: Regulation, Physiology, and Diseases

ISBN-13: 9780367538194 / Angielski / Twarda / 2023 / 240 str.

Jie Zheng; Matthew C. Trudeau

Opis

The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs.

Volume III includes coverage of key ion channel regulators and their mechanisms, the role of ion channels working in concert in selected physiological systems, and examples of ion channel mutations and dysfunction in a selection of diseases. Chapters on ion channel regulation include splice variants, calcium-calmodulin regulation, regulation by G-proteins, and lipids. A selection of ion channels in physiological systems includes ion channels of the heart, ion channels in immune cells and their role in pancreatic beta cells and regulation of insulin secretion, and the role of channels in sperm and eggs. While disease mechanisms are integrated into the chapters of Volume II, Volume III offers special consideration of ion channels in epilepsy, cystic fibrosis, and pain syndromes.

All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.

Spis treści

1. Alternative Splicing  2. Calmodulin Regulation of Ion Channels  3. Mechanism of G-protein Regulation of Ion Channels  4. Regulation of Ion Channels by Membrane Lipids  5. Ion Channels of the Heart  6. Ion Channels in Sperm and Eggs  7. Ion Channels in Immune Cells  8. Ion Channels in Epilepsy  9. Ion Channels in Pain  10. Cystic Fibrosis and the CFTR Anion Channels  11. CLC-Related Proteins in Diseases  12. KATP Channels and the Regulation of Insulin Secretion