Textbook of Ion Channels Volume II: Properties, Function, and Pharmacology of the Superfamilies

ISBN-13: 9780367538163 / Angielski / Twarda / 2023 / 496 str.

Jie Zheng; Matthew C. Trudeau

Opis

The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs.

Volume II starts with ion channel taxonomy and features coverage of major ion channel families and describes the physiological role, structural components, gating mechanisms and biophysics, permeation and selectivity, regulation, pharmacology and roles in disease mechanisms. Channels in this volume include voltage-activated sodium, calcium and potassium channels, inward-rectifier and two-pore domain potassium channels, calcium-activated potassium channels, cyclic-nucleotide gated channels, pacemaker ion channels, chloride channels, the ligand-gated receptors activated by acetylcholine, glutamate, 5-HT3, GABA and glycine, acid-sensing channels, P2X receptors, TRP channels, store-operated channels, pressure-activated piezo channels, ryanodine receptors and proton channels.

All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.

Spis treści

1. Taxonomy and Evolution of Ion Channels  2. Voltage-Gated Sodium Channels  3. Voltage-Gated Calcium Channels  4. Voltage-Gated Potassium Channels  5. ERG Family of K Channels  6. KCNQ Channels  7. BK Channels  8. Small-Conductance Calcium-Activated Potassium (SK) Channels  9. Inward Rectifier Potassium Channels  10. Two-Pore Domain Potassium Channels  11. Cyclic Nucleotide-Gated Channels  12. HCN Channels  13. CLC Chloride Channels and Transporters  14. Ca-Activated Cl- Channels  15: Acetylcholine Receptors  16. Ionotropic Glutamate Receptors  17. 5-HT3 Receptors  18. GABAA Receptors  19. Glycine Receptors  20. Acid Sensing Ion Channels  21: ENaC Channels  22. TRPC Channels  23. TRPM Channels  24. TRPV Channels  25. Store-Operated CRAC Channels  26. Piezo Channels  27. Ryanodine Receptors  28. Proton Channels  29. P2X Receptors