Testosterone: From Basic to Clinical Aspects

ISBN-13: 9783319834368 / Angielski / Miękka / 2018 / 414 str.

Hohl, Alexandre

Opis

Research on testosterone is increasing in many senses; however there is still much controversy regarding its physiology and clinical use. This book addresses these topics, providing a broad overview about testosterone, from its basic features to the most recent evidence of clinical applicability. Also, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. Although not essential for survival, testosterone represents the essence of male biological function, being the important testicular androgen in men. Low serum testosterone levels are associated with cardiovascular morbidity, metabolic syndrome, type 2 diabetes mellitus, atherosclerosis, osteoporosis, sarcopenia, and mortality. Conversely, increased serum levels of testosterone may lead to deleterious events. In general, there is increasing evidence that serum testosterone is a major biomarker status of men's health in general.Testosterone: From Basic to Clinical Aspects is an indispensable reference for all those who seek state-of-the-art knowledge regarding this hormone, from basic issues (including pharmacology and physiology) through clinical aspects (related diseases and supplementation therapy).

Spis treści

1. The history of testosterone: from antiquity to modern times.- 2. Testosterone: molecules and receptors.- 3. Physiology of male gonadotropic axis and disorders of sex development.- 4. Utility and limitations in measuring testosterone.- 5. Male puberty delayed and early.- 6. Hypogonadotropic and hypergonadotropic hypogonadism.- 7. Functional hypogonadism: diabetes mellitus, obesity, metabolic syndrome and testosterone.- 8. Male hypogonadism and aging.- 9. Male hypogonadism and traumatic brain injury.- 10. Male hypogonadism and fertility.- 11. Testosterone therapy: oral androgens.- 12. testosterone therapy: transdermal androgens.- 13. Testosterone therapy: injectables androgens.- 14. Benefits and adverse events of testosterone therapy.- 15. Testosterone and sexual function.- 16. Testosterone and prostate.- 17. Testosterone and cardiovascular effects.- 18. Testosterone and women.- 19. Testosterone and endocrine disruptors 20. Misuse and abuse of androgens.

O autorze

Alexandre Hohl MD, MSc, PhD, BPharm, by the Federal University of Santa Catarina (UFSC), Brazil. Endocrinologist by the Brazilian Society of Endocrinology and Metabolism; guest professor at UFSC; researcher at the Center for Applied Neurosciences - UFSC. Current president of the Brazilian Society of Endocrinology and Metabolism.