Testosterone: Action - Deficiency - Substitution

ISBN-13: 9783642721878 / Angielski / Miękka / 2011 / 598 str.

Eberhard Nieschlag; Hermann M. Behre

Opis

The first edition of "Testosterone: Action, Deficiency, Substitu tion" was published in 1990. Since then our understanding of the hormone that turns males into men has tremendously increased. Therefore, the editors felt that a second extended edition of the book is warranted in order to summarize established and recent findings in the field and to present the reader with an up-to-date is reflected by the textbook. The increased mass of knowledge growth of the volume from 14 to 20 chapters. In the updated edition the biochemistry and metabolism of androgens have been complemented by extensive information on the molecular biology of the androgen receptor and its disorders. The key role of testosterone in spermatogenesis is now better de fined. We have a more complete understanding of the psychotro pic effects of testosterone and know so much about the different target organs and functions that individual chapters deal with testosterone and the prostate, lipids and the cardiovascular sys tem, hair, bones and muscles. The general chapter on pharmacol ogy and clinical uses of testosterone, in particular in male hypo gonadism, is extended by pharmacokinetic studies on testoster one preparations and individual substitution modalities using testosterone esters as well as implants and advanced trans dermal applications. The physiologic basis and possible clinical applica tions of testosterone in non-gonadal diseases, in male senes cence, in hormonal male contraception and in transsexuals are discussed. The last chapter describes the role of "investigative" steroid biochemistry applied to tracking anabolic steroid abuse."

Spis treści

Testosterone - Overview of Biosynthesis, Transport, Metabolism and Non-genomic Actions of Testosterone. The Androgen Receptor - Physiology and Pathophysiology. Behavioural Correlates of Testosterone. The Role of Testosterone in Spermatogenesis. Androgens and Hair. Androgens and Bone Metabolism. Androgens and Muscles. Androgens - Cardiovascular Risk Factors and Atherosclerosis. Androgens and the Prostate. Pharmacology and Clinical Uses of Testosterone. Comparative Pharmacokinetics of Testosterone Esters. Clinical Pharmacology of Testosterone Pellet Implants. Long-term Experience with Testosterone Replacement Through Scrotal Skin. A Permeation-enhanced Non-scrotal Testosterone Transdermal System for the Treatment of Male Hypogonadism. Percutanous Dihydrotestosterone Treatment. Androgens in Male Senescence. Androgen Therapy in Non-gonadal Disease. Testosterone in Male Contraception. Androgen Treatment of Female-to-male Transsexuals. Abuse of Androgens and Detection of Illegal Use.

Blurb

New developments in testosterone action and therapy are summarized here by internationally renowned experts. They review both basic and clinical knowledge in 20 chapters. This 2nd edition has been thoroughly revised and extended. The book presents the biochemistry of testosterone, its biosynthesis, metabolism and mechanisms of action in target organs. Effects on bones, muscles, lipids, hair, the prostate, and the brain are considered in separate chapters. Syndromes caused by androgen resistance are described in order to highlight the importance of properly functioning enzymes and receptors in the target organs. The pharmacology, pharmacokinetics and clinical uses and abuses of testosterone preparations are discussed in detail, and side effects of testosterone treatment are reviewed. This is the state-of-the-art book about testosterone action and therapy for endocrinologists, andrologists, urologists and pharmacologists.