Testicular Function: From Gene Expression to Genetic Manipulation

ISBN-13: 9783662036730 / Angielski / Miękka / 2013 / 314 str.

Mario Stefanini; Carla Boitani; Michaela Galdieri

Opis

This volume contains the text of the main lectures given by interna tionally recognized scientists at the Tenth European Workshop on Mo lecular and Cellular Endocrinology of the Testis, held in Capri, Italy, from 28 March to 1 April 1998. Topics include spermatogonial transplantation, germ stem cell biol ogy, regulation of meiosis and spermiogenesis, growth factors, cell sig naling and transduction, steroidogenesis, androgen-regulated genes, sperm activation and sperm factors active at fertilization and the mo lecular basis of specific pathologies of the testis. Looking back at the previous "Capri edition" (1986), the lectures of which were published by Elsevier, it is perhaps not surprising to notice that many of the top ics addressed at that time are basically the same now. On the other hand, it appears evident that the search for experimental models of sig nificant physiological value to study testicular function has advanced greatly. In this connection, the use of genetically manipulated animal models in the study of the regulation of spermatogenesis and of the en docrine role of the testis represents a core part of the present volume. The authors deserve our special thanks not only for delivering ex cellent state-of-the-art lectures, but also for providing their manuscripts well before the meeting.

Spis treści

1 Gap Junctional Communication and the Regulation of Multicellular Functions.- 2 Experimental In Vitro Approaches to the Study of Mouse Primordial Germ Cell Development.- 3 Spermatogonial Transplantation.- 4 Genetic Control of Meiosis and the Onset of Spermiogenesis in Drosophila.- 5 Chromatin Structure and Gene Expression During Spermatogenesis.- 6 The Control of Testis ACE Expression.- 7 Growth Hormone Releasing Hormone and Growth Hormone Releasing Hormone-Related Peptide in the Testis.- 8 Cyclic ADP-Ribose and Calcium Signalling.- 9 Human Gonadotropin Receptors: Pathophysiology, Pharmacology, and Molecular Mechanisms.- 10 Steroidogenic Acute Regulatory Protein and Steroidogenesis.- 11 Pem: an Androgen-Dependent Homeodomain Gene Expressed in the Testis and Epididymis.- 12 Studies on the Mechanism of Sperm Production.- 13 Role of c-kit in Egg Activation.- 14 Spermatogenesis-Specific Genes Deleted in Infertile Men: DAZ/DAZH Clinical Aspects and Animal Models.- 15 Follicle-Stimulating Hormone Receptor Mutation and Fertility.- Previous Volumes Published in this Series.

Blurb

This volume contains the text of the plenary lectures given by internationally recognized experts in the field of gametogenesis and endocrinology at the 10th European Workshop on Molecular and Cellular Endocrinology of the Testis. Topics include spermatogonial transplantation, germ stem cell biology, regulation of meiosis and spermiogenesis, growth factors, cell signaling and transduction, steriodogenesis, androgen-regulated genes, sperm activation and sperm factors active at fertilization. The present volume pays particular attention to the use of genetically manipulated animal models in the study of the regulation of spermatogenesis and testicular functions.