Testicular Autoimmunity: A Cause of Male Infertility

ISBN-13: 9784431544593 / Angielski / Twarda / 2017 / 232 str.

Masahiro Itoh

Opis

It has long been suspected that testicular autoimmunity could be one of the causes of idiopathic male infertility. However, it is very difficult to estimate the incidence of testicular autoimmunity in men, as most male patients first realize they are infertile when they start trying to conceive a child, and there is a possibility that their testes may already exhibit the end stage of testicular autoimmunity, in which lymphocytic inflammation and immunoglobulin deposition in their testes subsided long ago and only the spermatogenic disorder remains. Therefore, autopsy or biopsy for testicular tissues in men before the end stage of testicular autoimmunity and investigations using testicular autoimmunity model animals are needed to determine the epidemiology of testicular autoimmunity. In this book, the author discusses "the immunological fragility of testis," reviewing the autopsy data in men and presenting experimental data using murine models of autoimmune orchitis that has been induced by immunizing with viable syngeneic testicular germ cells alone. Testicular autoimmunity in animals is also discussed. In summary, the book provides useful information not only to researchers who are interested in immunologic male infertility, but to clinical professionals who treat these patients at hospitals.

Spis treści

Chapter 1            Biological background of testicular autoimmunity.-

Chapter 2            Microcircumstance for induction and prevention of testicular autoimmunity.-

Chapter 3            Human testicular autoimmunity as a result of breakdown of testicular immune privilege.-

Chapter 4            Testicular autoimmunity by immunization with testicular antigens alone in experimental animals.-

Chapter 5            Testicular autoimmunity by the systemic treatment with immuno-potentiating agents in experimental animals.-

Chapter 6            Testicular autoimmunity by local injury of the testis in experimental animals.-&a

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Chapter 7            Testicular autoimmunity in experimental animals induced by manipulation of the   immune system.-

Chapter 8            The future directions of testicular autoimmunity investigation.

O autorze

Dr. Masahiro Itoh obtained Ph.D. degree in Division of Medicine, Kagawa University, in 1987. he started his carrier as an assistant professor at Kagawa University, and promoted to full Professor in 2001, at Tokyo Medical University. He is one of the top scientists in Japan and well-known as he succeeded in making new murine models of autoimmune orchitis.

Blurb

This book addresses various aspects of testicular autoimmunity. It has long been suspected that testicular autoimmunity could be one of the causes of idiopathic male infertility. However, it is very difficult to estimate the incidence of testicular autoimmunity in men, as most male patients first realize they are infertile when they start trying to conceive a child, and there is a possibility that their testes may already exhibit the end stage of testicular autoimmunity, in which lymphocytic inflammation and immunoglobulin deposition in their testes subsided long ago and only the spermatogenic disorder remains. Therefore, autopsy or biopsy for testicular tissues in men before the end stage of testicular autoimmunity and investigations using testicular autoimmunity model animals are needed to determine the epidemiology of testicular autoimmunity.

Accordingly, the book discusses “the immunological fragility of testis” with regard to male infertility, reviewing aut

opsy data in men and presenting experimental data using murine models of autoimmune orchitis that has been induced by immunizing with viable syngeneic testicular germ cells alone. Testicular autoimmunity in animals is also discussed. 

In summary, the book provides a wealth of valuable information, not only for researchers who are interested in immunologic male infertility, but also for clinical professionals who treat these patients at hospitals.