Teratology in the Twentieth Century Plus Ten

ISBN-13: 9789048188192 / Angielski / Twarda / 2010 / 266 str.

Harold Kalter

Opis

Serious congenital malformations are a major contributor to the infant death rate worldwide. Their nonhereditary causes are multiple and complex, and include infectious and metabolic dangers, disease medication, nutritional inadequacy, medicinal products, environmental agents and pollutants, among them. The cause of many however is still unknown. The wide range of these causes makes the defects of interest to those of a wide range of medical and investigatory backgrounds, especialy clinicians, fundamental scientists, and environmentalists.

Spis treści

INTRODUCTORY MATTERS Definition Classification Frequency PIONEERING STUDIES X-irradiation Rubella Other infectious diseases Intrauterine infection in animals PIONEERING WORKS Vitamin deficiency Hale and vitamin A deficiency Warkany and riboflavin deficiency EARLY EXPERIMENTS Vitamin A and diaphragmatic hernia Trypan blue Hypoxia Cortisone studies and by-products Vitamin antimetabolites NEW CHALLENGES THALIDOMIDE TESTING FOR TERATOGENICITY TERATOLOGICAL DETOURS Bendectin Blighted potatoes Female sex hormones Diethylstilbestrol SURVEILLANCE OF CONGENITAL MALFORMATIONS EPIDEMIOLOGY OF CONGENITAL MALFORMATIONS HUMAN DISEASE AS TERATOGEN Phenylketonuria Insulin-dependent diabetes mellitus Fever ENVIRONMENTAL HAZARDS AND DISASTERS Iodine deficiency Organic mercury Agent Orange Seveso Sellafield Chernobyl Polychlorinated biphenyls Love Canal: a study in political teratology DISEASE MEDICATION AND TERATOGENESIS Retinoids Synthetic retinoids Antiepileptic drugs Lithium FOLIC ACID AND HUMAN MALFORMATIONS ALCOHOL CONSUMPTION DURING PREGNANCY THE ACCOMPLISHMENT AND THE EXPECTATION