Tectona Grandis - A Useful Herb

ISBN-13: 9783659000607 / Angielski / Miękka / 2012 / 88 str.

Jitendra Bhangale; S. R. Chaudhari; S. R. Acharya

Opis

The aqueous extract of Tectona grandis bark (ATG) was investigated for anti-inflammatory and antinociceptive activity at the doses (p.o.) of 100, 200 and 400 mg/kg body weight. The acetic acid-induced writhing response, tail immersion test and hot plate test were used to assess antino-ciceptive activity. For evaluation of anti-inflammatory activity, carrageenan induced paw edema served as acute model. At a dose, ATG (100, 200 and 400 mg/kg, p.o.) significantly attenuated the writhing responses induced by an intraperitoneal injection of acetic acid and at ATG (200 and 400 mg/kg, p.o.) significantly increased pain latencies in tail immersion and hot plate test. In addition, the higher doses of ATG (200 and 400 mg/kg, p.o.) were inhibited carrageenan induced paw edema. From acute oral toxicity studies (OECD-423 guidelines), no mortality was observed even at highest dose of ATG (2000 mg/kg, p.o.).

O autorze

Jitendra Bhangale completed M. Pharm. DIPL from Bharati Vidyapeeth University's Poona College of Pharmacy, Pune, Maharashtra, India & currently working as Assistant Professor & Head, Department of Pharmacology, at Smt. N. M. Padalia Pharmacy College, Ahmedabad, Gujarat, India.