Technetium-99m Pharmaceuticals: Preparation and Quality Control in Nuclear Medicine

ISBN-13: 9783540339892 / Angielski / Twarda / 2006 / 368 str.

Ilse Zolle

Opis

Radioactive drug development is a multi-disciplinary task, therefore, in a concerted effort, dedicated scientists and experts from different fields of specialisation have contributed to this book. It is presented in two sections. Section 1 contains basic principles and methods used for analysis, information on the chemistry of technetium and on radiopharmaceuticals labelled with technetium-99m, the characteristics of the 99 Mo/99mTc-generator, of 'kits' and formulations for in-vitro labelling, and special safety aspects for in-vivo labelling of blood cells. Section 2 contains monographs of 99mTc-radiopharmaceuticals used in nuclear medicine. Each monograph includes information on the chemistry, formulation, commercial products and trade names, factors affecting in-vivo performance, clinical information on pharmacokinetics, as well as details concerning the clinical application and the radiation dose to patients.

Recenzje

From the reviews:

"This nicely organized and clearly illustrated book provides an up-to-date resource for radiopharmacists and nuclear medicine physicians who compound and prescribe ^99mTc-labeled radiopharmaceuticals. Radiochemists and those concerned with regulatory affairs also will be interested, and the book could be used as a primary text in nuclear medicine training programs. This outstanding book fills a void and is the first compilation of its kind in many years. We recommend it with the highest enthusiasm." (Susan Z. Lever and John R. Lever, Journal of Nuclear Medicine, May, 2009)

Spis treści

I.- Drug Safety.- Technetium in Medicine.- Stannous Chloride in the Preparation of 99mTc Pharmaceuticals.- Quality Assurance of Radiopharmaceuticals.- Performance and Quality Control of the 99Mo/99mTc Generator.- Preparation of Technetium 99mTc Pharmaceuticals.- Lyophilization Technique for Preparing Radiopharmaceutical Kits.- Cellular Labeling with 99mTc Chelates: Relevance of In Vitro and In Vivo Viability Testing.- Quality Control Methods of 99mTc Pharmaceuticals.- Other Technetium Isotopes: 94mTc as a Potential Substitute in Positron Emission Tomography Investigations.- The Rules Governing Medicinal Products for Human Use in the European Union.- II.- Monographs of 99mTc Pharmaceuticals.

O autorze

Radioactive drug development is a multi-disciplinary task, therefore, in a concerted effort, dedicated scientists and experts from different fields of specialization have contributed to this book. It is presented in two sections. Section 1 contains basic principles and methods used for analysis, information on the chemistry of technetium and on radiopharmaceuticals labeled with technetium-99m, the characteristics of the 99 Mo/99mTc-generator, of 'kits' and formulations for in-vitro labeling, and special safety aspects for in-vivo labeling of blood cells. Section 2 contains monographs of 99mTc-radiopharmaceuticals used in nuclear medicine. Each monograph includes information on the chemistry, formulation, commercial products and trade names, factors affection in-vivo performance, clinical information on pharmacokinetics, as well as details concerning the clinical application and the radiation dose to patients.

Blurb

This textbook gives an account of the accomplishments related to the development of ^99mTc-radiopharmaceuticals and their application in diagnostic nuclear medicine. Since radioactive drug development is a multi-disciplinary task, experts working in nuclear medicine and research institutions have contributed valuable information concerning the preparation with sterile kits, methods of quality control, and the use of ^99mTc-radiopharmaceuticals in patients. In addition, the legal aspects governing production and clinical application are also considered. Section 1 contains basic principles and methods used for analysis. Special emphasis is given to the analytical methods verifying pharmaceutical quality. Section 2 contains monographs of 99mTc-radiopharmaceuticals used in nuclear medicine. Each monograph includes information on the chemistry, formulation, commercial products and trade names, factors affection in-vivo performance, clinical information on pharmacokinetics, as well as details concerning the clinical application and the radiation dose to patients. This book can serve for daily practice in nuclear medicine, serving as a reference source as well as a teaching tool.