Targeting Lysine Demethylases in Cancer and Other Human Diseases

ISBN-13: 9783031381751 / Angielski / Twarda / 2023

Opis

This book provides a comprehensive summary of our current knowledge on lysine demethylases, a class of epigenetic regulators. It takes the reader on an exciting journey spanning the past two decades, starting from the initial discovery and characterization of these enzymes and leading up to the development of their small molecule modulators. These modulators have shown promise in clinical trials and hold great potential to improve patient outcomes. The book captures the progress made in this field and highlights the significant advancements that have paved the way for potential therapeutic applications.

The book covers a wide range of topics, spanning both basic biology and clinical implications associated with lysine demethylases. It offers a comprehensive historical and conceptual framework for the discovery and characterization of similar epigenetic enzymes or modulators. Chapter one serves as an introductory overview, providing insights into the general characteristics and functions of lysine demethylases. In subsequent chapters, specifically chapters two to eight, each major family of lysine demethylases is individually explored in depth. By providing in-depth insights into the functional aspects of these enzymes, the book allows readers to grasp their significance in regulating cellular processes and influencing pathogenesis. Moreover, the book goes beyond fundamental knowledge and also explores the development of diagnostic and therapeutic strategies related to lysine demethylases. It highlights the potential for utilizing these enzymes as therapeutic targets for the treatment of various diseases, including cancer and infectious diseases. Additionally, the book highlights future directions aimed at further unraveling the roles of lysine demethylases and translating these findings into the clinic.

Spis treści

Chapter 1. Lysine demethylation in pathogenesis

Jian Cao, Qin Yan

Chapter 2. Targeting the LSD1/KDM1 Family of Lysine Demethylases in Cancer and Other Human Diseases

Fei Mao, Yujiang Shi

Chapter 3. KDM2 demethylases as drug targets

Jaclyn Andricovich1 and Alexandros Tzatsos

Chapter 4. Role of histone demethylase KDM3 (JMJD1) in transcriptional regulation and cancer progression

Lingling Fan, Songhui Xu, Jianfei Qi

Chapter 5. KDM4 demethylases as drug targets

Yuanyuan Jiang, Lanxin Liu, Zeng-Quan Yang

Chapter 6. KDM5 lysine demethylases in pathogenesis, from basic science discovery to the clinic

Shang-Min Zhang, Jian Cao, Qin Yan

Chapter 7. Context-dependent functions of lysine demethylases in physiology and disease

Mina Masoumeh Tayari, Celestia Fang, Panagiotis Ntziachristos

Chapter 8. KDM7 demethylases as drug targets

Peng Shao, Qi Liu, Hank Heng Qi