Targeting Cell Survival Pathways to Enhance Response to Chemotherapy: Volume 3

ISBN-13: 9780128164327 / Angielski / Twarda / 2018 / 308 str.

Daniel E. Johnson

Spis treści

1. Targeting Members of the Epidermal Growth Factor Receptor Family to Improve Response to Chemotherapy2. Targeting the Hepatocyte Growth Factor Receptor to Overcome Resistance to Targeted Therapies3. Roles for AXL and MERTK in Resistance to Cytotoxic and Targeted Therapies4. The JNK Pathway in Drug Resistance5. Fibroblast Growth Factor Receptor (FGFR) Inhibitors: Enhancing Therapeutic Strategies for Solid Tumors6. PIK3CA Mutations in Colorectal and Breast Cancer: Impact on Oncogenesis and Response to Nonsteroidal Anti-inflammatory Drugs7. STAT3 as a Major Contributor to Chemoresistance8. Targeting the Hippo Pathway to Improve Response to Chemotherapy9. Modulation of the Epigenome (Methylome) to Improve Chemotherapeutic Efficacy10. Targeting the ATR Signaling Pathway to Overcome Chemoresistance in Cancer11. PARP Inhibition to Enhance Response to Chemotherapy12. Autophagy Inhibition and Chemosensitization in Cancer Therapy13. Targeting Necroptosis in Anti-Tumor Therapy

O autorze

Benjamin Bonavida, PhD, has been involved in the field of immunology and cancer biology for several decades and has published extensively in the fields of cancer resistance, chemotherapy, immunotherapy, and various molecular approaches to circumvent the resistance of the cancer cells using sensitizing agents. Accordingly, he was the first to publish a book on tumor sensitization in 2008. More recently, Dr. Bonavida is the Series Editor of 3 series published by Elsevier/Academic Press ("Cancer Sensitizing Agents for Chemotherapy,” "Breaking Cancer Resistance to Therapeutic Antibodies,” and "Breaking Tolerance to Anti-Cancer Immunotherapy”) and several books have been published and many are in development. He has published extensively in the field of NK biology and cytotoxicity in the past, and many of these publications were in collaboration with the co-editor Dr. Anahid Jewett. Daniel E. Johnson received his undergraduate degrees in chemistry and mathematics from North Park University in Chicago, Illinois. He received his doctoral degree in molecular biology from Princeton University under the mentorship of Dr. Mark A. Bothwell. His postdoctoral research was done under the mentorship of Dr. Lewis T. Williams at the University of California at San Francisco (UCSF). He joined the faculty at the University of Pittsburgh and the University of Pittsburgh Cancer Institute in 1993, where he served as Professor of Medicine and Scientific Director of the Acute Leukemia Working Group. In 2016, he moved to UCSF where he is currently Professor in the Department of Otolaryngology - Head and Neck Surgery. Dr. Johnson has served as a standing member on National Institutes of Health and American Cancer Society study sections and has been a Section Editor for the journal Leukemia since 2001. His research is focused on anti-cancer drug development and the elucidation of cell death and cell survival signaling pathways in head and neck cancer and leukemia. He has additional interests in the development of chemopreventive agents and strategies. Dr. Johnson places particular emphasis on translating laboratory findings to the clinic and has collaborated extensively with physician scientists to initiate and conduct clinical trials in head and neck cancer and acute myeloid leukemia. .