TT Viruses: The Still Elusive Human Pathogens

ISBN-13: 9783642089985 / Angielski / Miękka / 2010 / 233 str.

Ethel-Michele de Villiers;Harald zur Hausen

Opis

Eleven years ago the circular DNA of a novel single-stranded virus has been cloned and partially characterized by Nishizawa and Okamoto and their colleagues. According to the initials of the patient from whom the isolate originated, the virus was named TT virus. This name has been subsequently changed by the International Committee on Taxonomy of Viruses (ICTV) into Torque teno virus, permitting the further use of the abbreviation TTV. Although initially suspected to play a role in non A -E hepatitis, subsequent studies failed to support this notion. Within a remarkably short period of time it became clear that TT viruses are widely spread globally, infect a large proportion of all human populations studied thus far and represent an extremely heterogeneous group of viruses, now labelled as Anelloviruses. TT virus-like infections have also been noted in various animal species. The classification of this virus group turns out to be difficult, their DNA contains between 2200 and 3800 nucleotides, related so-called TT-mini-viruses and a substantial proportion of intragenomic recombinants further complicate attempts to combine these viruses into a unifying phylogenetic concept.

Spis treści

History of Discoveries and Pathogenicity of TT Viruses.- Classification of TTV and Related Viruses (Anelloviruses).- TT Viruses in Animals.- Replication of and Protein Synthesis by TT Viruses.- Immunobiology of the Torque Teno Viruses and Other Anelloviruses.- Intragenomic Rearrangement in TT Viruses: A Possible Role in the Pathogenesis of Disease.- TT Viruses: Oncogenic or Tumor-Suppressive Properties?.- Relationship of Torque Teno Virus to Chicken Anemia Virus.- Apoptosis-Inducing Proteins in Chicken Anemia Virus and TT Virus.- Chicken Anemia Virus.- Geminiviruses.

Blurb

Within a remarkably short period of time it became clear that TT viruses are widely spread globally, infect a large proportion of all human populations studied thus far and represent an extremely heterogeneous group of viruses, now labelled as Anelloviruses. TT virus-like infections have also been noted in various animal species. The classification of this virus group turns out to be difficult, their DNA contains between 2200 and 3800 nucleotides, related so-called TT-mini-viruses and a substantial proportion of intragenomic recombinants further complicate attempts to combine these viruses into a unifying phylogenetic concept. Although studied in many laboratories, the medically most interesting question of their possible pathogenic role in humans remains unanswered until today. It is not unreasonable to suspect that persistence of at least some specific TT virus genotypes may result in some infected individuals in a definable pathogenicity. We believe that this volume provides first hints in support of this view