T-Box Genes in Development and Disease: Volume 122

ISBN-13: 9780128013809 / Angielski / Twarda / 2017 / 444 str.

Manfred Frasch

Opis

T-box Genes in Development and Disease looks at the genes encoding the T-box family of transcription factors function as key regulators of many important decision processes during embryonic and tissue development. The importance of these genes is further underlined by the fact that most members of this gene family have been conserved during evolution from worms to humans. This book brings together the current information on conserved aspects with the evolutionary innovations of the functions of these genes during developmental regulation in various animal species and then discusses their important roles in human disease.

• Brings together current knowledge from a wide variety of animal species and humans
• Presents commentary from authoritative experts, and includes many prominent scientists and their research
• Illuminates the connections between developmental biology, evolution, and human disease
• Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge

Spis treści

1. Evolution and Classification of the T-Box Transcription Factor Family A. Sebé-Pedrós and I. Ruiz-Trillo 2. The Remarkably Diverse Family of T-Box Factors in Caenorhabditis elegans P.G. Okkema 3. T-Box Genes and Developmental Gene Regulatory Networks in Ascidians A. Di Gregorio 4. Eomesodermin - At Dawn of Cell Fate Decisions During Early Embryogenesis S. Probst and S.J. Arnold 5. Cooperation Between T-Box Factors Regulates the Continuous Segregation of Germ Layers During Vertebrate Embryogenesis G.E. Gentsch, R.S. Monteiro and J.C. Smith 6. T-Box Genes in Drosophila Mesoderm Development I. Reim, M. Frasch and C. Schaub 7. TBX5: A Key Regulator of Heart Development J.D. Steimle and I.P. Moskowitz 8. Tbx1: Transcriptional and Developmental Functions A. Baldini, F.G. Fulcoli and E. Illingworth 9. T-Box Genes in the Kidney and Urinary Tract A. Kispert 10. Control of Neuronal Development by T-Box Genes in the Brain A.B. Mihalas and R.F. Hevner 11. T-Box Genes in Drosophila Limb Development G.O. Pflugfelder, F. Eichinger and J. Shen 12. The Roles of T-Box Genes in Vertebrate Limb Development C.J. Sheeba and M.P.O. Logan 13. T-Box Genes in Human Development and Disease T.K. Ghosh, J.D. Brook and A. Wilsdon

O autorze

Manfred Frasch is chair of the Division of Developmental Biology in the Department of Biology at Friedrich-Alexander-University of Erlangen-Nürnberg in Germany. From 1991 to 2006 he was on the faculty of Mount Sinai School of Medicine, New York, where he retains an Adjunct Professor status. Prior to that, Frasch received his Ph.D. degree from Tübingen University, Germany, then performed his postdoctoral training with Michael Levine at Columbia University in New York, and subsequently had a junior group leader position at the Max-Planck-Institute for Developmental Biology in Tübingen. Frasch is a Pew Scholar in the Biomedical Sciences and, from 2013 to 2015, served as chair of the Society of Developmental Biology, Germany (GfE). He has had a long-standing interest in the genetic and molecular mechanisms of muscle and heart development, with a main focus on Drosophila, and has authored over 90 articles and papers.