Systems Biology of Tumor Dormancy

ISBN-13: 9781461414445 / Angielski / Twarda / 2012 / 294 str.

Heiko Enderling; Nava Almog; Lynn Hlatky

Opis

The first annual CCSB workshop brought together biologists, mathematicians, and computer scientists to discuss various aspects of tumor dormancy and develop novel mathematical/computational models with the keynote speakers. This title is based on the Workshop on Systems Biology of Tumor Dormancy meeting, held July 25th to July 28th, 2011.

Spis treści

Foreword.- Preface.- Part 1: Angiogenesis.- Genes and Regulatory Pathways Involved in Persistence of Dormant Micro-Tumors.- The Host Support Niche as a Control Point for Tumor Dormancy – Implications for Tumor Development and Beyond.- Insights into the Regulation of Tumor Dormancy by Angiogenesis in Experimental Tumors.- Part 2: Stem Cells and Signaling Pathways.- Cancer Stem Cells and Tumor Dormancy.- Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy.- Tumor Dormancy, Oncogene Addiction, Cellular Senescence and Self Renewal Programs.- Part 3: Immune System.- Multifaceted Kinetics of Immuno-Evasion from Tumor Dormancy.- Tumor Dormancy and Cancer Stem Cells: Two Sides of the Same Coin?.- Tumor Dormncy: Long-Term Survival in a Hostile Environment.- A Review of Mathematical Models of Cancer-Immune Interactions in the Context of Tumor Dormancy.- Part 4: Mathematical Biosciences and Dynamical Systems Modeling.- Regulation of Tumor Dormancy and Role of Microenvironment: A Mathematical Model.- Seeing the Invisible.- How Mathematical Models Uncover Tumor Dormancy, Reconstruct the Natural History of Cancer, and Assess the Effects of Treatment.- Index.