Systems Biology of Apoptosis

ISBN-13: 9781461440086 / Angielski / Twarda / 2012 / 204 str.

Inna Lavrik

Opis

Systems Biology of Apoptosis summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this book, the editor describes the contemporary systems biology studies devoted to apoptotic signaling and focuses on the question how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies.

Spis treści

Preface.- Modeling formalisms in systems biology of apoptosis.- Systems biology of death receptor-induced apoptosis.- Systematic complexity reduction of signaling models and application to a CD95 signaling model for apoptosis.- Systems Biology of the Mitochondrial Apoptosis Pathway.- Systems biology of cell death in hepatocytes.- Understanding different types of cell death using Systems Biology.- Modeling Single Cells in Systems Biology.- Cytokine-cytokine crosstalk and cell-death decisions.- Genetic and genomic dissection of apoptosis signaling.- Index.

Blurb

Apoptosis is highly defined programmed cell death, which leads to the elimination of cells. Deregulation of programmed cell death is associated with serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. In recent years, apoptosis has been successfully studied using a systems biology approach. Systems biology is a novel field of science which combines mathematical modeling with experimental data leading to predictions of biological processes. The development of this field in recent years is fascinating. Studies of apoptosis using systems biology have provided novel insights into the quantitative regulation of cell death.

In Systems Biology of Apoptosis, contemporary systems biology studies devoted to cell death signaling both from experimental and modeling sides is discussed, as well as a focus on how systems biology helps to understand life/death decisions made in the cell and the development of new approaches to rational treatment strategies.