Systems Biology and In-Depth Applications for Unlocking Diseases: Principles, Tools, and Application to Disease

ISBN-13: 9780443223266 / Angielski

Babak Sokouti

Spis treści

Part 1. Introduction1.1 Systems biology at a glance1.2. A history on systems biology evolution1.3. Brief information on cellular biology and signaling pathways1.4. Systems biology: where are we?1.5. Filling the gaps between systems biology and cell biology1.6 Concluding remarks1.7 Mathematical concepts1.5. Kinetic and dynamics of biological systems

Part 2. Tools and Resources2.1. Biological data sources2.1.1. Microarray 2.1.2. Next generation sequencing (NGS)2.1.3. Comparative genomic hybridization (CGH)2.1.4. Single nucleotide polymorphisms (SNP)2.2. High throughput data2.1.2. Databases2.3. Programming, tools and software

Part 3. Systems biology in action - to understand diseases3.1 Big data analysis techniques

3.2 Reconstruction of genome and proteomic scale network structures and functions

3.3 Validation strategies3.3.1 Mathematical model development 3.3.2 Biological gene expression models3.3.3 Experimental techniques

3.4 Applications of systems biology extensions in diseases3.4.1 Systems immunology3.4.2 Systems pharmacology3.4.3 Systems virology3.4.4 Systems vaccinology3.4.5 Systems neuroscience3.4.6 Systems medicine3.4.7 Future directions on systems biology