Systems Biology

ISBN-13: 9781493974559 / Angielski / Twarda / 2017 / 364 str.

Mariano Bizzarri

Opis

This volume focuses on methodological aspects of systems biology in order to provide a new theoretical approach with a robust and tailored experimental support. Chapters detail mathematical modeling, methodological issues, modulation of the collective behavior, metabolic, dynamic profiling, and quantitative morphological studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Systems Biology aims to ensure successful results in the further study of this vital field.

Spis treści

1. Conceptual Challenges in the Theoretical Foundations of Systems Biology

Marta Bertolaso and Emanuele Ratti

 

2. An Integrative Approach toward Biology, Organism

s, and Cancer

Carlos Sonnenschein and Ana M. Soto

 

3. Conceptual Challenges of the Systemic Approach in Understanding Cell Differentiation

Andras Pald

i

 

4. A Primer on Mathematical Modeling in the Study of Organisms and their Parts

Maël Montévil

 

5. The Search for System’s Parameters

Alessandro Giuliani

 

6

.  Inverse Problems in Systems Biology: A Critical Review

Rodolfo Guzzi, Teresa Colombo, and Paola Paci

 

7. Systems Biology Approach and Mathematical Modeling for Analyzing Phase-space Switch during Epithe

lial-mesenchymal Transition

Chiara Simeoni, Simona Dinicolab, Alessandra Cucina, Corrado Mascia, and Mariano Bizzarri

 

8.

Parameters Estimation in Phase-space Landscape Reconstruction of Cell Fate; A Systems Biology Approach

S. Montero, R.R. Martin, R. Mansilla, G. Cocho, and J.M. Nieto-Villar

 

9. Complexity of Biochemical and Genetic Responses Reduced using Simple Theoretical Models

Kumar Selvarajoo

 

10. Systems Biology Modelling of Non-linear Cancer Dynamics

Christian Cherubini, Simonetta Filippi, and Alessandro Loppini

 

11. Endogenous Molecular-cellular Network Cancer Theory: A Systems Biology Approach 

Gaowei Wang, Ruoshi Yuan, Xiaomei Zhu, and Ping Ao

 

12. A Network-based Integrative Workflow to Unravel Mechanisms Underlying Disease Progression

Faiz M. Khan, Mehdi Sadeghi, Shailendra K. Gupta, and Olaf Wolkenhauer

 

13. Spatiotemporal Fluctuation Analysis of Molecular Diffusion Laws in Live-cell Membranes

Francesco Cardarelli

 

14. A Method for Cross-species Visualization and Analysis of RNA-sequence Data

Stephen A. Ramsey

 

15. Multi Agent Simulations of Population Behavior (A Promising Tool for Systems Biology)  

Alfredo Colosimo 

 

16.

Metabolomics: Challenges and Opportunities in Systems Biology Studies

Luca Casadei, Mariacristina Valerio, and Cesare Manetti

 

17.  Systems Biology-driven Hypotheses Tested In Vivo: The Need to Advancing Molecular Imaging Tools

Garima Verma, Alessandro Palombo, Maura Grigioni, Morena La Monaca, and Giuseppe D’Avenio