Synthesis and Biological Evaluation Of New Quinoline Compounds

ISBN-13: 9783330054080 / Angielski / Miękka / 2017 / 84 str.

Bandapally Chandrakanth; Girija Sastry

Opis

Quinolines as a class of antibacterial agents have been known for over 40 years. Although considerable results in the research of new antibacterial quinolines have already been achieved, they are still a matter of study because of the continuous demand of new compounds active against resistant strains of bacteria. Research efforts are mainly focused on obtaining new compounds active against very resistant bacterial strains or acting on the mechanisms of resistance. Therefore efforts were made in the synthesis of new derivates for quinoline nucleus. The 4-amino-3-formylquinoline-2-(1H)-one (Q10-Q12) was obtained by the formylation of 2, 4-dichloroquinoline (Q1-Q3). All the synthesized compounds have been characterized by using elemental analysis, spectroscopical studies. All the synthesized compounds were tested for their antibacterial and antifungal activity. The compounds also tested for in-vitro antioxidant activity. The compounds exhibited significant antibacterial, antifungal and anti-oxidant activities. These compounds can be further exploited to get the potent lead compounds.

O autorze

Research in the field hetero cycle compounds & Analytical chemistry and various drug delivery systems and published 36 international & 4 national journals & visited 2 universities in U.S.A.Attended various international & national conferences.Working as principal of Aurobindo college of pharmaceutical sciences.Guided 42 PG students & 1 Ph.D Fellow.