Synthesis, Antioxidant and Antimicrobial Activity of New Thiophene

ISBN-13: 9786208065805 / Angielski / Miękka / 2025 / 92 str.

Manisha Devi; Kaushal Arora; Prabhakar Kumar Verma

Opis

In the current scenario, the Gewald synthesis mechanism was used to synthesize a series of 11 newly designed thiophene analogs (D1-D11) derivatives using (Scheme-1, D1-D11). FTIR, 1H-NMR are used for the characterization of the newly synthesized analogs. After structural characterization, these derivatives are then screened for their in vitro biological evaluation. The biological evaluation of designed thiophene analogs was performed to test their antibacterial, antifungal and antioxidant action. Among all the designed and synthesized analogs, compounds D11 and D6 exhibit strong antibacterial action against Escherichia coli and Bacillus subtilis. Compound D3 and D11 has the strongest antifungal properties towards Aspergillus clavatus Compound D3 and D11 produces the greatest antioxidant activity with an IC50 value of 51.18 and 49.60.