Symposium on Biophysics and Physiology of Biological Transport: Frascati, June 15-18, 1965

ISBN-13: 9783709155790 / Angielski / Miękka / 2012 / 342 str.

Liana Bolis; V. Capraro; K. R. Porter

Opis

The study of cell membranes began to attract increasing interest before the turn of the present century with the observations of 0 verton. Since that time many investigators have become interested in the broad problem of structure and function of the membrane and today we find ourselVes at a stage in which several branches of research, particularly physical chemistry, biochemistry, biophysics, physiology and pharmacology have come together, leading to the possibility of obtaining a better perspective of the overall problems. The purpose of this Symposium was to assemble in an orderly sequence representations of the knowledge of membranes achieved to date in the areas of the various disciplines. It was thought that to bring together many points of view on a problem should allow the conferees to see better what had been accomplished, what has been overlooked and what needs further development. It is to be hoped that efforts of this type have and will fulfill the desired purpose. This volume contains the majority of the papers contributed by the participants in the Symposium.In addition, it seemed logical to place at the beginning of each chapter at least one general survey of the subject which would help those who were less acquainted with the problem to derive the most benefit from their reading.

Spis treści

I. Phenomena of Membrane Physiology.- A.- Invited Papers.- Transport of Metabolites.- Ion Transport in Excitable Cells.- Electrolyte and Water Transport across Epithelial Cells.- Some Aspects of the Functional Polarity of Epithelia.- Amino Acid Absorption through Intestinal Epithelium.- Some Biochemical Aspects of Amino Acid Transport.- Na+-Dependent Transport of Carbohydrates through Intestinal Epithelium.- Intestinal Absorption of Fat.- Contributed Papers.- Studies on the Intercellular Junctions of Mesothelium and Endothelium.- Energy Metabolism and Ion Transport Studied in Single Neurons.- Some Aspects of Glucose Transport in Kidney Cortex Slices.- Relationships between the Natriferic Action of Oxytocin and the Active Transport of Sodium through the Frog’s Skin.- Effect of 5-Hydroxytryptamine on Sodium Transport across Bullfrog Skin.- Cellular Aspects of Membrane Permeability.- Role of Intestinal Disaccharidases in Sugar Transport.- Temporal Resolution of Heat Exchange during Action Potential of Nerve.- B: Secretion, Phagocytosis, and Intracellular Transport.- Invited Papers.- Energetics of Transport.- Exchange of Macromolecules between Nucleus and Cytoplasm.- Phagocytosis and Related Phenomena.- Active Ion Transport by Mitochondria.- Lysosomes and Phagosomes (The Vacuolar Apparatus).- Contributed Papers.- The Nature of Thermodynamic Coupling in Transport Processes.- Contributed Papers.- The Effect of Metabolic Inhibitors on Pinocytosis in Amoebae.- Effects of Some Substances on Release of Acid Hydrolases of Rat Liver.- Distribution and Turnover of the Phosphatides in the Intracellular Membranes and in the Myelin Sheaths of the Rat Brain.- C: Transport and Drugs.- Invited Papers.- Enzymes, Drugs, and Transport Phenomena.- Transport of Drugs across Membranes.- Contributed Papers.- Transport of Biological Amines as an Element of Drug Action.- Effects of Insulin on Glucose Transport in Chick Embryo Heart.- Biophysical Aspects of Ionic Transfer across Membranes in Relation to the Mode of Action of Diuretics.- Absorption through Intestinal Epithelium as Influenced by Phospholipids.- Effect of Cardiac Glycosides on Active Na-K-Transport.- The Effect of Prostaglandin E1 on Free Fatty Acid Mobilization and Transport.- II Membrane Structure.- A: Molecular Organization of Unit Membrane.- Invited Papers.- Structure and Physical Chemistry of Membranes.- On the Lipid Composition of Membranes.- Interrelationship between Lipids and Proteins in Membranes.- Surface Properties of Molecular Aggregates of Micellar Size in Relation to Membrane Permeability and Adhesion.- Contributed Papers.- Monomolecular Films at Saline Fluorocarbon Interfaces.- Structural and Biochemical Features of Isolated Cell Surface Membranes.- Liquid Ion Exchange Membranes of Extreme Ionic Selectivity and High Transmissivity.- Lipid Interactions in Aqueous Surfaces, Membranes and Micellar Systems.- B: Membrane Models.- Invited Papers.- The Diffusion of Ions from a Phospholipid Model Membrane System.- Structural Role of Water in Lipoprotein Systems.- Experimental Bilayer Membrane Models.- Surface Lattices and Membrane Design.- Contributed Papers.- Possible Location of Phospholipids and Structural Protein in Mitochondrial Membranes.- Comparison of Theories of Teorell’s Membrane Oscillator.- Electron Microscopy of Negatively-stained Lipids.- The Effects of Negative Stains on Lipids and Proteins Observed in the Electron Microscope.- Electron Microscopy of Fixed Lipids.- C: Electron Microscopy and X-ray Diffraction.- Invited Papers.- Origin of the Unit Membrane Concept.- X-ray Diffraction Studies of Cell Membranes.- The Structure of Cellular Membranes.- contributed Papers.- Specializations of the Unit Membrane.- Mitochondrial Cristae during Liver Regeneration.- Some Ultrastructural Aspects of Cell Membranes.- III. Mechanisms of Transport.- Invited Papers.- General Aspects of the Transport of Matter across Non-semipermeable Membranes.- Active Transport and Metabolism.- Chemical Control of Excitable Membranes during Electrical Activity.- Carrier Mechanisms.- The Enzymatic Basis for the Active Transport of Sodium and Potassium.- Contributed Papers.- Isolation of a Protein Coded for by the Permease Gene of the Lac Operon of Escherichia coli.- Evidence for a Carrier-mediated Transfer Model for the Accumulation of 14C-?-Aminobutyric Acid by Brain Particles at Zero Degrees Centigrade.- Sodium-dependent Metabolism and Transport of ?-Aminobutyric Acid in Subcellular Particles from Brain.- Countercurrent Principle.- Compartmental Models in the Analysis of Intestinal Absorption.- IV. Concluding Remarks.- Concluding Remarks at the “Symposium on Biophysics and Physiology of Biological Transport”.