Section I: Hydrophilic-lipophilic difference (HLD) fundamentals1. The HLD-NAC in a nutshell: an introduction to the principles and uses of HLD-NAC2. History and evolution of the HLD3. Surfactant mixtures and the measurement of characteristic curvature (Cc)4. Oil mixtures and the measurement of equivalent alkane carbon number (EACN)5. Effect of electrolytes, polymers, co-solvents and additivesSection II: Hydrophilic-lipophilic difference (HLD) applications6. Use of HLD in Surfactant-Enhanced Oil Recovery and Aquifer Remediation7. Use of HLD for corrosion inhibitors and flow assurance chemicals8. Use of HLD in Detergent formulations9. Use of HLD in Fragrance formulation10. High-throughput HLD phase scans for surfactant characterization and formulation11. HLD-guided surfactant design for enhanced oil recovery applications12. High-throughput HLD-guided formulation design for latex and agrochemical formulations13. HLD-guided surfactant structure-performance relationship in cold detergency applications14. HLD-guided design of self-emulsifying drug delivery applications15. HLD-guided design of vegetable oil extraction technologySection III: Net-Average Curvature (NAC) fundamentals16. History and evolution of NAC17. Prediction of phase diagrams for surfactant-oil-water (SOW) and surfactant-water (SW) systems18. Prediction of interfacial tension, rigidity, emulsion formation and stability19. Prediction of oil-water-solid wettabilitySection IV: Applications of the net-average curvature20. HLD-NAC in practical applications21. HLD-NAC in reservoir simulation22. HLD-NAC alternatives in reservoir simulation23. HLD-NAC design of hard surface cleaning systems24. HLD-NAC design of microemulsion-templated nanoparticles25. HLD-NAC design of microemulsion-templated nanostructured polymers26. HLD-NAC guided design of extended surfactants for enhanced oil recovery operationsSection V: The Integrated Free Energy Model (IFEM)27. Derivation and predictive capabilities of the Integrated Free Energy model28. Applications of IFEM in detergent formulation development