Sunlight, Vitamin D and Skin Cancer

ISBN-13: 9781493904365 / Angielski / Twarda / 2014 / 539 str.

Jorg Reichrath

Opis

The goal of this volume is to comprehensively cover a highly readable, updated and extended, overview on our present knowledge of positive and negative effects of UV-exposure, with a focus on vitamin D and skin cancer. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in endocrinology, epidemiology, histology, photobiology, immunology, cytogenetics and molecular pathology to new concepts for prophylaxis and treatment. Experts in the field as well as health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of the second edition of this book to summarize essential up-to-date information for every clinician or scientist interested in how to balance between positive and negative effects of UV-exposure to minimize the risks of developing vitamin D deficiency and skin cancer.

Spis treści

Sunlight, Ultraviolet-Radiation, Vitamin D and Skin Cancer: How Much Sunlight Do We Need?.- Vitamin D and Cancer: An Overview on Epidemiological Studies.- Vitamin D Status and Cancer Incidence and Mortality.- Solar Ultraviolet Irradiance and Cancer Incidence and Mortality.- Vitamin D Receptors Polymorphisms and Cancer.- The Role of Vitamin D for Cardiovascular Disease and Overall Mortality.- Epidemiology of Skin Cancer.- Histology of Melanoma and Nonmelanoma Skin Cancer.- Cytogenetics of Melanoma and Nonmelanoma Skin Cancer.- The Immune System and Skin Cancer.- Human Papillomaviruses and Skin Cancer.- Ultraviolet Damage, DNA Repair and Vitamin D in Nonmelanoma Skin Cancer and in Malignant Melanoma: An Update.- Molecular Biology of Basal and Squamous Cell Carcinomas.- Solar Ultraviolet-Radiation, Vitamin D and Skin Cancer Surveillance in Organ Transplant Recipients (OTRS): An Update.- Therapy of Metastatic Malignant Melanoma: On the Way to Individualized Disease Control.- The Vitamin D Receptor: A Tumor Suppressor in Skin.- Protection from Ultraviolet Damage and Photocarcinogenesis by Vitamin D Compounds.- Interaction of Hedgehog and Vitamin D Signaling Pathways in Basal Cell Carcinomas.- Solar Ultraviolet Exposure and Mortality from Skin Tumors.- Ultraviolet Radiation and Cutaneous Malignant Melanoma.- Sun Exposure and Melanomas on Sun-Shielded and Sun-Exposed Body Areas.- Sunlight, Vitamin D and Malignant Melanoma: An Update.- Ultraviolet Exposure Scenarios: Risks of Erythema from Recommendations on Cutaneous Vitamin D Synthesis.- Ultraviolet-Radiation and Health: Optimal Time for Sun Exposure.- Sunscreens.- Sunscreens in the United States: Current Status and Future Outlook.- Health Initiatives for the Prevention of Skin Cancer.- Optimal Serum 25-Hydroxyvitamin D Levels for Multiple Health Outcomes.

O autorze

Jörg Reichrath is Professor for Dermatology and Deputy Director of the Clinic for Dermatology, Allergology and Venerology at the Saarland University Hospital in Homburg/Saar, Germany. Main research interests include photobiology, dermato‑endocrinology and dermato‑oncology. He is a member of numerous national and international scientific organizations, including the German Dermatological Society (DDG), the Deutsche Krebsgesellschaft (DKG), and the German Dermatologic Co‑operative Oncology Group (DeCOG). He has been awarded numerous prizes including the Arnold Rikli-Prize 2006. Jörg Reichrath received his academic degrees (Dr. med., venia legendi) from the Saarland University, Germany.