Sunlight, Vitamin D and Skin Cancer

ISBN-13: 9781441926579 / Angielski / Miękka / 2010 / 323 str.

Jorg Reichrath; J. Rg Reichrath

Opis

UV exposuie represents the most important risk factor for the development of nonmelanoma skin cancer. Additionally, assessment of sun exposure parameters has consistently shown an association between the development of malignant melanoma and short term, intense UV exposure, particularly burning in childhood. As a consequence, protection of the skin from UV exposure is an integral part of skin cancer prevention programs. However, more chronic, less intense UV exposure has not been found to be a risk factor for melanoma and in fact has been found in some studies to be protective. Moreover, 90% of all requisite vitamin D is formed within the skin through the action of the sun--a serious problem--for a connection between vitamin D deficiency and various types of cancer (e. g., colon, prostate and breast cancers) has been demonstrated in a large number of studies. Hence, the - sociation between vitamin D deficiency and various internal malignancies has now opened a debate among dermatologists and other clinicians how to balance between positive and negative effects of solar and artificial UV exposure. The goal of this volume is to provide a comprehensive, highly readable overview of our present knowledge of positive and negative effects of UV exposure, with a focus on vitamin D and skin cancer.

Recenzje

From the reviews:

"Small print, information dense and richly referenced volume ... of the current knowledge on this controversial topic. The text covers history, epidemiology, biochemistry, histology, immunology, and molecular biology. ... Lactation consultants depend on advice from public health officials to counsel their clients as well as to care for their own families. They can confidently use the content of this book to pressure officials to formulate recommendations that are more in line with the needs of the general population, including breastfeeding babies." (Nicole J Bernshaw, International Lactation Consultant Association Print and Multimedia Reviews, August, 2008)

Spis treści

CONTENTS 1. Sunlight, UV-Radiation, Vitamin D and Skin Cancer: How Much Sunlight Do We Need?....................................................... 1 Michael F. Holick Abstract................................................................................................................................. 1 Prehistorical and Historic Perspectives.............................................................................. 1 Photoproduction of Vitamin D3............................................................................................ 2 Factors Controlling Cutaneous Vitamin D Synthesis........................................................ 2 Sources and Metabolism of Vitamin D................................................................................ 4 Role of Vitamin D in the Prevention of Chronic Diseases................................................. 5 Vitamin D Deficiency Pandemic.......................................................................................... 7 Sunlight, Vitamin D and the Skin Cancer Conundrum.................................................... 7 Conclusion.......................................................................................................................... 10 2. Solar Ultrav iolet Irradiance and Cancer Incidence and Mortality...................................................................... 16 William B. Grant Introduction........................................................................................................................ 16 Cancer................................................................................................................................. 16 Other Diseases for Which Solar UVB and Vitamin D Are Beneficial/Protective.......... 25 Summary and Conclusion.................................................................................................. 25 3. Vitamin D Status and Cancer Incidence and Mortality............................................................................................. 31 Edward Giovannucci Introduction........................................................................................................................ 31 Ecologic Studies of Sun Exposure..................................................................................... 32 Case-Control and Cohort Studies of Sun Exposure........................................................ 32 Prospective Studies of Circulating 25(OH)vitamin D and Cancer Risk........................ 33 Studies of Vitamin D Intake............................................................................................... 35 Randomized Trial of Vitamin D Intake and Colorectal Cancer..................................... 36 Solar Radiation, Vitamin D and Survival Rate of Colon Cancer................................... 36 Vitamin D and Cancer Rates in United States Black Men.............................................. 37 Synthesis of Evidence Regarding Sun Exposure, Vitamin D and Cancer Incidence and Mortality........................................................................ 38 Implications for Future Research...................................................................................... 39 4. Sun Exposure and Cancer Surviva l in Norway: Changes in the Risk of Death with Season of Diagnosis and Latitude.................................................................... 43 Alina Carmen Porojnicu, Arne Dahlback and Johan Moan Abstract............................................................................................................................... 43 Introduction.............................................

O autorze

Jörg Reichrath is Professor for Dermatology and Deputy Director of the Clinic for Dermatology, Allergology and Venerology at the Saarland University Hospital in Homburg/Saar, Germany. Main research interests include photobiology, dermato-endocrinology and dermato-oncology. He is a member of numerous national and international scientific organizations, including the German Dermatological Society (DDG), the Deutsche Krebsgesellschaft (DKG), the German Dermatologic Cooperative Oncology Group (DeCOG), and the European Society of Dermatological Research (ESDR). He has been awarded numerous prices including the Arnold-Rikli-price 2006. Jörg Reichrath received his academic degrees (Dr. med., venia legendi) from the Saarland University, Germany.