Studies on the Potential Antidepressant Activity of Cannabinoids » książka
Studies on the Potential Antidepressant Activity of Cannabinoids
ISBN-13: 9783843387873 / Angielski / Miękka / 2012 / 292 str.
Could cannabinoids be antidepressant? chronic administration of the phytocannabinoids (THC, CBD) as well as rimonabant had no antidepressant-like effect in normal rats. However, chronic administration of THC and rimonabant had antidepressant-like effects in the OB-model of depression. Given the emergence of anxiety and depression in patients treated with rimonabant, this opens a debate about the predictive validity of animal models for drug effects in humans
Could cannabinoids be antidepressant? chronic administration of the phytocannabinoids (THC, CBD) as well as rimonabant had no antidepressant-like effect in normal rats. However, chronic administration of THC and rimonabant had antidepressant-like effects in the OB-model of depression. Given the emergence of anxiety and depression in patients treated with rimonabant, this opens a debate about the predictive validity of animal models for drug effects in humans
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