Structure and Function of the Neural Cell Adhesion Molecule NCAM

ISBN-13: 9781441911698 / Angielski / Twarda / 2009 / 434 str.

Vladimir Berezin

Opis

Dr. Elisabeth Bock (Photo Keenpress) This book contains review articles that produce a snapshot of recent developments in the field of the neural cell adhesion molecule NCAM. The chapters are grouped into sections reflecting various aspects of NCAM structure and function. The themes cover the structural basis of cell adhesion mediated by NCAM and NCAM interaction partners, NCAM-mediated signaling determinants of NCAM function under physiological conditions and in disease, and the therapeutic potential of NCAM mimetics. Section 1, "Structure and Ligands of NCAM," introduces the reader to the str- tural basis of NCAM-mediated cell adhesion, discussing the current knowledge of extracellular and intracellular NCAM ligands and the structural basis of NCAM int- actions with the fibroblast growth factor (FGF) receptor. Section 2, "NCAM and Polysialic Acid," focuses on NCAM polysialylation, discussing the structural and functional aspects of the most important posttranslational modifications of NCAM by the addition of a long linear homopolymer of sialic acid to the fifth Ig-like NCAM module. Section 3, "NCAM-mediated Signal Transduction," is devoted to signal v BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011 BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011 vi Preface transduction mechanisms associated with NCAM-mediated adhesion, with a focus on signaling pathways involved in NCAM-mediated neurite outgrowth, the role of growth-associated proteins, signaling through lipid microdomains, and signaling crosstalk with the epidermal growth factor (EGF) receptor. Section 4, "NCAM Metabolism," focuses on current knowledge about NCAM biosynthesis and the g- eration and role of soluble NCAM.

Spis treści

Preface Structural Biology of NCAM Vladislav Soroka, Christina Kasper and Flemming M. Poulsen Extracellular Protein Interactions Mediated by NCAM: Heterophilic Interactions between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses Janne Nielsen, Nikolaj Kulahin and Peter S. Walmod Intracellular Ligands of NCAM Bettina Büttner and Rüdiger Horstkorte NCAM and the FGF receptor Vladislav V. Kiselyov The Role of ATP in the Regulation of NCAM Function Martin V. Hübschmann and Galina Skladchikova Polysialylation of NCAM Herbert Hildebrandt, Martina Mühlenhoff and Rita Gerardy-Schahn Structural Basis for the Polysialylation of NCAM Karen J. Colley The Role of PSA-NCAM in Adult Neurogenesis Eduardo Gascon, Laszlo Vutskits and Jozsef Zoltan Kiss Use of PSA-NCAM in Repair of the Central Nervous System Abderrahman El Maarouf and Urs Rutishauser Signaling Pathways Involved in NCAM-induced Neurite Outgrowth Dorte Kornerup Ditlevsen and Kateryna Kolkova Role of Growth-Associated Protein GAP-43 in NCAM-mediated Neurite Outgrowth Irina Korshunova, Mark Mosevitsky NCAM and Lipid Rafts Gro Klitgaard Povlsen and Dorte Kornerup Ditlevsen NCAM and Epidermal Growth Factor Receptor: Signaling Crosstalk Gro Klitgaard Povlsen Biosynthesis of NCAM Kateryna Kolkova Soluble NCAM Thomas Secher Role of NCAM in Spine Dynamics and Synaptogenesis Dominique Muller, Pablo Mendez, Mathias De Roo, Paul Klauser, S. Steen and Lorenzo Poglia NCAM in Long-termPotentiation and Learning Barbara P. Hartz and Lars Christian B. Rønn Role of NCAM in Emotion and Learning Lisa Conboy, Reto Bisaz, Kamila Markram and Carmen Sandi NCAM in Neuropsychiatric and Neurodegenerative Disorders Leann H. Brennaman and Patricia F. Maness NCAM in Cancer: Expression and Mechanisms Silvia Zecchini and Ugo Cavallaro NCAM Mimetic Peptides: An Update Vladimir Berezin and Elisabeth Bock Synthetic NCAM-derived Ligands of the FGF receptor Stine Maria Hansen, Shizhong Li, Elisabeth Bock and Vladimir Berezin Dendritic Spine and Synapse Morphological Alterations Induced by an NCAM Mimetic Michael Stewart, Victor Popov, Nilolai Medvedev, Paul Gabbott, Nicola Corbett, Igor Kraev and Heather Davies Fasciclin II: The NCAM Ortholog in Drosophila melanogaster Lars V. Kristiansen and Michael Hortsch The Neural Cell Adhesion Molecule NCAM2/OCAM/RNCAM: A Close Relative of NCAM Nikolaj Kulahin and Peter S. Walmod Honoring Dr. Elisabeth Bock Vladimir Berezin

Blurb

Adhesive interactions are important for cell trafficking, differentiation, function and tissue formation. In the nervous system, many cell adhesion molecules (CAMs) are involved in migration of neuroblasts, outgrowth and fasciculation of neuronal processes, formation of synapses and rearrangements of synaptic contacts associated with plasticity including learning and memory. More than eighty CAMs were found to be localized at synaptic sites, where they in a regulated manner bridge pre- and postsynaptic specializations thereby modulating synaptic function. Structure and Function of the Neural Cell Adhesion Molecule NCAM describes recent developments concerning structural, functional and possible therapeutic aspects of one particular CAM, the neural cell adhesion molecule (NCAM). NCAM is one of the first identified and most studied CAMs, and this book is the first attempt to collectively summarize our current knowledge of this important cell adhesion molecule.