Structure and Function of Intrinsically Disordered Proteins

ISBN-13: 9781420078923 / Angielski / Twarda / 2009 / 359 str.

Peter Tompa

Opis

Disordered, as opposed to ordered, proteins cover nearly half of the sequence space in various proteomes, yet to date they have received little mention in references. This work provides the first comprehensive reference on the structure, function, and evolution of intrinsically disordered proteins (IDPs). After an overview of protein science principles, it examines biophysical methods for characterizing IDPs, addressing computational approaches as well as major classes of relevant algorithms. The text also discusses structural and functional classification, including functional advantages to protein disorder. A section devoted to IDPs and disease examines intervention strategies.

Spis treści

Principles of Protein Structure and Function. A Brief History of Protein Disorder. Indirect Techniques for Recognizing and Characterizing Protein Disorder. Hydrodynamic Techniques. Spectroscopic Techniques for Characterizing Disorder. Nuclear Magnetic Resonance. Proteomic Approaches for the Identification of IDPs. IDPs under Conditions Approaching In Vivo. Prediction of Disorder. Structure of IDPs. Biological Processes Enriched in Disorder. Molecular Functions of Disordered Proteins. Evolution and Prevalence of Disorder. Extension of the Structure-Function Paradigm. Structural Disorder and Disease. References.

O autorze

Peter Tompa is Group Leader in the Laboratory of Intrinsically Disordered Proteins, Institute of Enzymology, Biological Research Center at the Hungarian Academy of Sciences in Budapest.