Strategies to Modify the Drug Release from Pharmaceutical Systems

ISBN-13: 9780081000922 / Angielski / Twarda / 2015 / 208 str.

Bruschi, Marcos Luciano

Opis

Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed.

• Addresses the principles, systems, applications and advances in the field of drug delivery
• Highlights the mathematical and physicochemical principles related to strategies
• Discusses drug release and its possible modifications

Spis treści

Chapter 1 - General considerations Pharmaceutics: Safety, quality and efficacy Conventional and alternative therapeutic regimens Chapter 2 - Modification of drug release Objectives Advantages Disadvantages History Chapter 3 - Classification of therapeutic systems for drug delivery Passives, pre-programmed Actives, programmed and controlled externally Actives, self-programmable Chapter 4 - Main mechanisms to control the drug release Diffusion Swelling Erosion Osmosis Others Chapter 5 - Mathematical and physicochemical models of drug release Chapter 6 - Drug delivery systems: Principles, local of administration, materials, characterization, applications, advances and the use of natural products Matrix Tablets Suspensions Osmotic Pumps Micro/nanoparticles Micro/nanoemulsioned systems Liposomes and niosomes Floating Systems Systems with cyclodextrins Transdermal systems Bio/mucoadhesive Systems Liquid crystalline systems Implant Biocompatible carriers Other systems

O autorze

Marcos Luciano Bruschi, Ph.D., is Professor of Pharmaceutics and

Pharmaceutical Technology in the Department of Pharmacy at the State

University of Maringá (UEM), Paraná, Brazil. He gained a BSc in Pharmacy

(1996 - UEM, Brazil), a MD in Pharmaceutical Sciences (2002 - State University

of São Paulo - UNESP - Brazil) and a PhD in Pharmaceutical Sciences (2006 -

University of São Paulo - USP - Brazil and School of Pharmacy, Queen's

University of Belfast, Northern Ireland, UK). In 2013-2014, he is accomplishing

a Post-Doctoral Degree in Pharmaceutics in the School of Pharmacy, Queen's

University of Belfast (QUB - Northern Ireland, UK). He is registered with the

Brazilian Pharmaceutical Society and, in 1998, took up a lectureship in

Pharmaceutics in the School of Pharmacy, UEM, Brazil. In 1999, he was

appointed as a senior lectureship and to a personal Chair in Pharmaceutics and

Pharmaceutical Technology in 2006. His research concerns the development

and characterization of pharmaceutical dosage forms and drug delivery

systems, using natural or synthetic sources. Dr. Bruschi's work has involved the

development of novel drug delivery systems, with particular emphasis on

micro/nanoparticles, semisolids, bio/mucoadhesives, thermoresponsive systems,

liquid crystaline phases, and natural products. He is the author of three Brazilian

patent requests and over 150 research papers/communications.