Strategies for Immunointerventions in Dermatology

ISBN-13: 9783642645396 / Angielski / Miękka / 2011 / 426 str.

G. Nter Burg; Reinhard G. Dummer

Opis

Recent progress in the fields of pharmacology and immunology has provided us with new possibilities for treating dermatological diseases. This book reviews the most important immunosuppressive and immunostimulatory drugs and gives helpful, practical information on the treatment of various dermatoses, including autoimmundiseases, atopic dermatitis, psoriasis, vasculitis, contact dermatitis, pyoderma gangrenosum, infectious diseases, and neoplasms of the skin - in particular, malignant melanoma.

Spis treści

1 Basic Aspects.- A Rational Approach to Immune Intervention.- Skin as an Immunocompetent Organ in Health and Disease.- 2 Immunosuppressive and Antiinflammatory Compounds.- Cyclosporin A.- Rapamycin.- FK-506/Tacrolimus.- Low-Dose Methotrexate: An Immunomodifying Therapeutic Strategy for Dermatologie Diseases.- Leflunomide.- Fusion Toxins.- Dermatological Phototherapy: A Prime Example of Ultraviolet Radiation-Induced Immunointervention.- Cytokines with Immunosuppressive Capacities.- Extracorporeal Photochemotherapy.- Glucocorticosteroids.- High-Dose Intravenous Immunoglobulins.- 3 Immunostimulatory Substances and Vaccination Therapies.- Interferon-a Therapy in Dermatology.- Tumor Necrosis Factors.- Cytokines and Cytokine Gene Transfer in Cancer Treatment.- Development of a DNA Vaccine Against Malignant Melanoma.- Low Molecular Weight Cytokine Inducers.- 4 Clinical Aspects of Immunosuppression and Immunostimulation.- 4.1 Dermatoses Treated with Immunosuppressives 217.- Autoimmune Bullous Diseases.- Rheumatic Disease Group.- Atopic Dermatitis.- Psoriasis - Mediation of Skin Phenotype by Circulatory Pathogenic T Lymphocytes.- Vasculitis Allergica.- Contact Dermatitis.- Pyoderma Gangrenosum.- 4.2 Dermatoses Treated with Immunostimulatory Drugs andVaccination Therapies 293.- 4.2.1 Infections 293.- Viral Infections: Human Papillomavirus Infections Treated with Immunostimulatory Drugs and Vaccination Therapies.- Immunostimulation and Vaccination Therapy of Human Immunodeficiency Virus Infection.- Cytokine Therapy and Vaccination in Tropical Diseases Leishmaniasis and Leprosy.- 4.2.2 Neoplasms321.- Cutaneous Lymphomas.- Non-melanoma Skin Cancer.- Therapy of Kaposi’s Sarcoma.- 4.2.3S trategies for Immunointervention in Malignant Melanoma357.- Adjuvant Melanoma Therapy.- Cytokine-Based Treatments for Advanced Melanoma.- Gene Therapy: A New Perspective for the Treatment of Malignant.- Topical Immunotherapy of Malignant Melanoma.- Vaccination with Dendritic Cells — A Specific Immunomodulatory Approach for the Treatment of Malignant Melanoma.

O autorze

Prof. Dr. Günter Burg ist Direktor der Hautklinik am Universitätsspital Zürich. Neben der Allg. Dermatologie sind Tumoren der Haut Schwerpunkte seiner wissenschaftlichen Arbeit. Zur deren Diagnostik und Therapie hat er mit seinem Team Wesentliches beigetragen.