Strategies and Tactics in Organic Synthesis: Volume 10

ISBN-13: 9780124171855 / Angielski / Twarda / 2014 / 320 str.

M Harmata

Opis

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, we are given stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done, and we are educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.

• Presents state-of-the-art developments in organic synthesis
• Provides insight and offers new perspective to problem-solving
• Written by leading experts in the field

Spis treści

1. The Substrate-Directed Heck-Matsuda Arylations. From Curiosity to a Valuable Synthetic Tool, Carlos Duarte Correia 2. (-)-Berkelic Acid: Lessons Learned from our Investigations on Scalable Total Synthesis, Francisco J. Fañanás 3. Replicating Nature's Schemes with Pericyclic Reactions, Kathlyn A. Parker 4. Total Synthesis of Chinensolide B: Overcoming Functional Group Selectivity and a Mislabeled Bottle of Carvone, Dennis Hall 5. The Synthesis of Borrerial and Flindersial Akaloids via Biosynthesis-Inspired Strategies, Jeremy A. May 6. Synthesis of (±)-Amathaspiramide F: Stereochemical Switch of a [2,3]-Stevens Rearrangement, Uttam Krishan Tambar 7. Halocylopropene Furan Cycloadditions: Application to the Total Synthesis of the Frondosins, Dennis Wright 8. Structure Inspires a New Method that Delivers the Synthesis of Natural Products and Analogs in the Pederin Family, Paul Floreancig 9. Gliocladin C: The Development of Visible Light Mediated, Catalytic Intermolecular Pyrroloindoline-indole Radical Coupling Reaction, Corey Stephenson 10. Adventures in Atropselective Synthesis, Jared Shaw 11. Sleepless Nights: The Total Synthesis of the Anticancer Australian Rainforest Polyketide EBC23, Craig McKenzie Williams 12. Total Synthesis of Crinipellin B, Hee-Yoon Lee

O autorze

Professor Michael Harmata graduated from the University of Illinois-Chicago with honors and highest distinction in chemistry.

In 1980, he began graduate studies in chemistry at the University of Illinois-Champaign/Urbana where he was awarded a University Teaching Fellowship. He worked with Professor Scott E. Denmark on the invention of the carbanion-accelerated Claisen rearrangement. In his second year of study, he was awarded an Eastman Kodak Research Fellowship.

Upon graduation in 1985, he was awarded an NIH postdoctoral fellowship which he used to study with Professor Paul A. Wender at Stanford University, where he worked on the synthesis of the neocarzinostatin chromophore.

In 1986, Prof. Harmata began his independent career at the University of Missouri-Columbia. He became an Associate Professor in 1992 and a full professor in 1998. In 2000, he was named the Norman Rabjohn Distinguished Professor of Chemistry in recognition of his achievements in research and teaching. In 1998, he received a research fellowship from the Alexander von Humboldt Foundation and stayed for a year at the University of Göttingen where he was affiliated with the groups of Professors Reinhard Brückner and Lutz. F. Tietze. In 2000, he served as chair of the Gordon conference on Organic Reactions and Processes. In 2010, he was named the first Justus Liebig Professor of Chemistry at the Justus Liebig Üniversität in Giessen, Germany. In 2011, he was a JSPS fellow. He has been a visiting professor in Giessen and Strasbourg and has delivered over 180 invited lectures in the United States and Europe. He is a member of the American Chemical Society, Gesellschaft Deutscher Chemiker, International Society of Heterocyclic Chemistry, and the Alexander von Humboldt Association of America.