Strategic Medical Science Against Brain Attack

ISBN-13: 9784431703372 / Angielski / Twarda / 2002 / 294 str.

O. I. Fedotov; H. Kikuchi; H. Kikuchi

Opis

The importance of the therapeutic time window for ischemic stroke has been widely accepted for a long time. Consequently, I have been thinking about the past, when the term "brain attack," which was reimported from the United States, began to spread by repetition. In the 1980s, I had made an enthusiastic study of acute-phase cerebral revascularization for ischemic stroke. At that time, we could cure only a quite lim ited number of patients, such as those who already were hospitalized or who, fortu nately, were brought to the hospital within a few hours from the onset of the stroke. RM Crowell, in his 1977 report on cases of failure, had identified the consider able problems in acute-phase cerebral revascularization as diagnosis of tissue reversibility, brain-protective reagents or methods, and effective techniques for revascularization. I remember that we strongly endorsed his opinion. Recently, the basic study of stroke has advanced significantly, resulting in newly developed materials and new experimental techniques, which are introduced in this book. I hope that new basic knowledge will be clinically applied."

Spis treści

I. Strategies using neuritic reconstruction and neuroregeneration: Neural stem cells as a tool for cell transplantation - Jun Takahashi. Repair of mammalian central nervous pathways: attempts to reconstruct normal neural connections with marked functional recovery - Saburo Kawaguchi.- II. Strategies of neuroprotection: MEK/ERK as targets for stroke treatment - Shoubu Namura. Redox regulation in neuronal damage during brain ischemia - Junji Yodoi. Gene structure and function of pituitary adenylate cyclase activating polyepeptide (PACAP) as a neurotrophic peptide - Kenji Kangawa. Neurite outgrowth-promoting prostaglandins that act as neuroprotective agents against brain ischemia and may enhance recovery of higher neuronal functions - Takumi Satoh.- III. Strategies using survival or death signals in neurons: Molecular mechanisms of neuronal survival roles of kinases in ischemic cell death - Yukiko Goto. Gene expression in injured neurons and the manipulation of the expression - Hiroshi Kiyama.- IV. Strategies for and from cortical spreading depression: Brain ischemia and spreading depression in a primate model - Kazuo Minematsu. Infarct tolerance induced by repetitive cortical spreading depression is reproduced by prolonged intracerebral infusion of recombinant brain-derived neurotrophic factor - Hiroji Yanamoto. V. Strategies using hypothermia: The importance of thermal changes in the pathophysiology of stroke: Post-stroke fever and hypothermia therapy - Hiroaki Naritomi. Cerebrovascular disease and hypothermia Part I: Effects of mild hypothermia in the management of cerebrovascular disease - Nobuyuki Yasui. Cerebrovascular disease and hypothermia Part ?: An experimental approach for ischemic neuronal death - Nobuyuki Yasui. Neuroprotection by mild hypothermia for temporary or permanent focal ischemia - Hiroji Yanamoto.- VI. Strategies for cerebral aneurysm and vasospasm: The roles of MMPs for cerebral aneurysm formation - Nobuo Hashimoto. Systemically administered thrombin inhibitors can prevent neointimal formation and cerebral vasospasm: The possible role of thrombin and PDGF-BB in vascular pathogeneses - Izumi Nagata. Cerebral vasospasm induced by the interaction between macrophage and oxidized membrane of erythrocyte - Tomoh Masaki.- VII. Developments in brain-imaging technology: Evaluation and analysis of brain attack using MR functional imaging - Chuzo Tanaka.