Steroid Hormone Receptors: Basic and Clinical Aspects

ISBN-13: 9781461598510 / Angielski / Miękka / 2012 / 522 str.

Opis

The past few years have witnessed the emergence of steroid hormones as the wonder molecules which generate as much discussion in the scientific literature as they do in a typical living room. This transition has been a result of the tremendous public and scientific interest in the normal functioning of the hor- mones as well their suggested involvement in several clinical conditions. In the recent past, notable scientific and technological advances have been made in the areas of contraception and regulation of fertility. Steroid receptors are the indis- pensable mediators of hormonal responses and are complex protein molecules which appear to exist in association with other, yet undefined, proteins and/or factors. Receptors for vitamin D, retinoic acid and the thyroid hormones share structural similarities with steroid receptors, and the roster of this superfamily is still expanding. While our knowledge of the diversity and magnitude of steroid effects has advanced, the precise mode of steroid hormone action has alluded investigators. This volume brings together an international team of prominent investigators who discuss their most recent work on the basic and clinical aspects of steroid/nuclear receptors. The contributions represent updated versions of the invited presentations made at The Second Meadow Brook Conference on Steroid Receptors in Health and Disease. I am grateful to my colleagues on the Scientific Committee: Etienne Baulieu, Jack Gorski, Benita Katzenellenbogen, David Toft and James WittJiff, who provided the vision and guidance in formulating an out- standing program.

Spis treści

I Introduction.- 1 Steroid/Nuclear Receptor Superfamily: Recent Advances and Relation to Health and Disease.- II Steroid Receptor Interactions with DNA and Nuclear Components.- 2 Structural and Functional Studies of Selective DNA Binding by Steroid/Nuclear Receptors.- 3 Estrogen Receptor Induced DNA Bending.- 4 The Nuclear Environment and Estrogen Action.- 5 Functional Interaction of the Estrogen Receptor with the Tissue-Specific, Homeodomain Transcription Factor, PIT-1.- 6 Insights into the Genomic Mechanism of Action of 1, 25-Dihydroxyvitamin D3.- 7 Molecular Mechanisms of Thyroid Hormone and Retinoic Acid Action.- III Receptor Structure and Associated Proteins.- 8 Heat Shock Proteins and the Cytoplasmic-Nuclear Trafficking of Steroid Receptors.- 9 In Vitro Assembly of the Avian Progesterone Receptor.- 10 Steroid Receptor Associated Proteins: Heat Shock Protein 90 and P59 Immunophilin.- 11 Estrogenic and Developmental Regulation of 90-Kilodalton Heat Shock Protein Gene Expression.- IV Receptor Modification and Hormone/Antihormone Interactions.- 12 Phosphorylation and Progesterone Receptor Function.- 13 Estrogen Receptor Activation by Ligand-Dependent and Ligand-Independent Pathways.- 14 Why Are Steroid Receptor Antagonists Sometimes Agonists?.- 15 Ligand Requirements for Estrogen Receptor Function and the Actions of Antiestrogens.- V Steroid Receptors and Clinical Correlations.- 16 Molecular Biological Aspects of the Human Androgen Receptor Relating to Disease.- 17 Estrogen Receptor Variants in Breast Cancer.- VI Emerging and Novel Systems.- 18 Human Bone Cells: Newly Discovered Target Cells for Sex Steroids.- 19 Characteristics of the Human Estrogen Receptor Protein Produced in Microbial Expression Systems.- 20 The Ah Locus: A Review.- Author Index.